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    Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial.

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    Authors
    Weber, J
    D'Angelo, S
    Minor, D
    Hodi, F
    Gutzmer, R
    Neyns, B
    Hoeller, C
    Khushalani, N
    Miller, W
    Lao, C
    Linette, G
    Thomas, L
    Lorigan, Paul C
    Grossmann, K
    Hassel, J
    Maio, M
    Sznol, M
    Ascierto, P
    Mohr, P
    Chmielowski, B
    Bryce, A
    Svane, I
    Grob, J
    Krackhardt, A
    Horak, C
    Lambert, A
    Yang, A
    Larkin, J
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    Affiliation
    Moffitt Cancer Center, Tampa, FL, USA.
    Issue Date
    2015-04
    
    Metadata
    Show full item record
    Abstract
    Nivolumab, a fully human IgG4 PD-1 immune checkpoint inhibitor antibody, can result in durable responses in patients with melanoma who have progressed after ipilimumab and BRAF inhibitors. We assessed the efficacy and safety of nivolumab compared with investigator's choice of chemotherapy (ICC) as a second-line or later-line treatment in patients with advanced melanoma.
    Citation
    Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial. 2015, 16 (4):375-84 Lancet Oncol
    Journal
    Lancet Oncology
    URI
    http://hdl.handle.net/10541/550190
    DOI
    10.1016/S1470-2045(15)70076-8
    PubMed ID
    25795410
    Type
    Article
    Language
    en
    ISSN
    1474-5488
    ae974a485f413a2113503eed53cd6c53
    10.1016/S1470-2045(15)70076-8
    Scopus Count
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