Browsing All Paterson Institute for Cancer Research by Authors
Author correction: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.Schumacher, FR; Olama, AAA; Berndt, SI; Benlloch, S; Ahmed, M; Saunders, EJ; Dadaev, T; Leongamornlert, D; Anokian, E; Cieza-Borrella, C; et al. (2019)In the version of this article initially published, the name of author Manuela Gago-Dominguez was misspelled as Manuela Gago Dominguez. The error has been corrected in the HTML and PDF version of the article.
Radiogenomics: radiobiology enters the era of big data and team science.Rosenstein, B; West, Catharine M L; Bentzen, S; Alsner, J; Andreassen, C; Azria, D; Barnett, G; Baumann, M; Burnet, N; Chang-Claude, J; et al. (2014-07-15)
A three-stage genome-wide association study identifies a susceptibility locus for late radiotherapy toxicity at 2q24.1.Fachal, L; Gómez-Caamaño, A; Barnett, G; Peleteiro, P; Carballo, A; Calvo-Crespo, P; Kerns, S; Sánchez-García, M; Lobato-Busto, R; Dorling, L; et al. (2014-06-29)There is increasing evidence supporting the role of genetic variants in the development of radiation-induced toxicity. However, previous candidate gene association studies failed to elucidate the common genetic variation underlying this phenotype, which could emerge years after the completion of treatment. We performed a genome-wide association study on a Spanish cohort of 741 individuals with prostate cancer treated with external beam radiotherapy (EBRT). The replication cohorts consisted of 633 cases from the UK and 368 cases from North America. One locus comprising TANC1 (lowest unadjusted P value for overall late toxicity = 6.85 × 10(-9), odds ratio (OR) = 6.61, 95% confidence interval (CI) = 2.23-19.63) was replicated in the second stage (lowest unadjusted P value for overall late toxicity = 2.08 × 10(-4), OR = 6.17, 95% CI = 2.25-16.95; Pcombined = 4.16 × 10(-10)). The inclusion of the third cohort gave unadjusted Pcombined = 4.64 × 10(-11). These results, together with the role of TANC1 in regenerating damaged muscle, suggest that the TANC1 locus influences the development of late radiation-induced damage.