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    Nuclear localization of the pre-mRNA associating protein THOC7 depends upon its direct interaction with Fms tyrosine kinase interacting protein (FMIP).

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    Authors
    El Bounkari, Omar
    Guria, Anuja
    Klebba-Faerber, Sabine
    Claussen, Maike
    Pieler, Tomas
    Griffiths, John R
    Whetton, Anthony D
    Koch, Alexandra
    Tamura, Teruko
    Affiliation
    Institut fuer Biochemie, OE4310 Medizinische Hochschule Hannover, Hannover, Germany.
    Issue Date
    2009-01-05
    
    Metadata
    Show full item record
    Abstract
    THOC7 and Fms-interacting protein (FMIP) are members of the THO complex that associate with the mRNA export apparatus. FMIP is a nucleocytoplasmic shuttling protein with a nuclear localization signal (NLS), whereas THOC7 does not contain a typical NLS motif. We show here that THOC7 (50-137, amino acid numbers) binds to the N-terminal portion (1-199) of FMIP directly. FMIP is detected mainly in the nucleus. In the absence of exogenous FMIP, THOC7 resides mainly in the cytoplasm, while in the presence of FMIP, THOC7 is transported into the nucleus with FMIP. Furthermore, THOC7 lacking the FMIP binding site does not co-localize with FMIP, indicating that THOC7/FMIP interaction is required for nuclear localization of THOC7.
    Citation
    Nuclear localization of the pre-mRNA associating protein THOC7 depends upon its direct interaction with Fms tyrosine kinase interacting protein (FMIP). 2009, 583 (1):13-8 FEBS Lett.
    Journal
    FEBS Letters
    URI
    http://hdl.handle.net/10541/53393
    DOI
    10.1016/j.febslet.2008.11.024
    PubMed ID
    19059247
    Type
    Article
    Language
    en
    ISSN
    1873-3468
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.febslet.2008.11.024
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research
    School of Cancer and Imaging Sciences

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