• Login
    View Item 
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Somervaille, Tim C P
    Matheny, Christina J
    Spencer, Gary J
    Iwasaki, Masayuki
    Rinn, John L
    Witten, Daniela M
    Chang, Howard Y
    Shurtleff, Sheila A
    Downing, James R
    Cleary, Michael L
    Affiliation
    Cancer Research UK Leukaemia Biology Group, Paterson Institute for Cancer Research, University of Manchester, Manchester, UK.
    Issue Date
    2009-02-06
    
    Metadata
    Show full item record
    Abstract
    The genetic programs that promote retention of self-renewing leukemia stem cells (LSCs) at the apex of cellular hierarchies in acute myeloid leukemia (AML) are not known. In a mouse model of human AML, LSCs exhibit variable frequencies that correlate with the initiating MLL oncogene and are maintained in a self-renewing state by a transcriptional subprogram more akin to that of embryonic stem cells (ESCs) than to that of adult stem cells. The transcription/chromatin regulatory factors Myb, Hmgb3, and Cbx5 are critical components of the program and suffice for Hoxa/Meis-independent immortalization of myeloid progenitors when coexpressed, establishing the cooperative and essential role of an ESC-like LSC maintenance program ancillary to the leukemia-initiating MLL/Hox/Meis program. Enriched expression of LSC maintenance and ESC-like program genes in normal myeloid progenitors and poor-prognosis human malignancies links the frequency of aberrantly self-renewing progenitor-like cancer stem cells (CSCs) to prognosis in human cancer.
    Citation
    Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells. 2009, 4 (2):129-40 Cell Stem Cell
    Journal
    Cell Stem Cell
    URI
    http://hdl.handle.net/10541/53373
    DOI
    10.1016/j.stem.2008.11.015
    PubMed ID
    19200802
    Type
    Article
    Language
    en
    ISSN
    1934-5909
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.stem.2008.11.015
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research
    Leukaemia Biology Group

    entitlement

    Related articles

    • Grist for the MLL: how do MLL oncogenic fusion proteins generate leukemia stem cells?
    • Authors: Somervaille TC, Cleary ML
    • Issue date: 2010 Jun
    • Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential.
    • Authors: Wong P, Iwasaki M, Somervaille TC, So CW, Cleary ML
    • Issue date: 2007 Nov 1
    • Homing and invasiveness of MLL/ENL leukemic cells is regulated by MEF2C.
    • Authors: Schwieger M, Schüler A, Forster M, Engelmann A, Arnold MA, Delwel R, Valk PJ, Löhler J, Slany RK, Olson EN, Stocking C
    • Issue date: 2009 Sep 17
    • Structural maintenance of chromosomes 4 is required for leukemia stem cell maintenance in MLL-AF9 induced acute myeloid leukemia.
    • Authors: Peng L, Tang Y, Zhang Y, Guo S, Peng L, Ye L, Wang Y, Jiang Y
    • Issue date: 2018 Oct
    • PBX3 is essential for leukemia stem cell maintenance in MLL-rearranged leukemia.
    • Authors: Guo H, Chu Y, Wang L, Chen X, Chen Y, Cheng H, Zhang L, Zhou Y, Yang FC, Cheng T, Xu M, Zhang X, Zhou J, Yuan W
    • Issue date: 2017 Jul 15
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.