• Are germ cell tumors part of the Li-Fraumeni cancer family syndrome?

      Hartley, Ann L; Birch, Jillian M; Kelsey, Anna M; Marsden, Henry B; Harris, Martin; Teare, Marion D; Department of Epidemiology and Social Oncology, Christie Hospital, Manchester, England. (1989-10-15)
      The occurrence of six cases of germ cell tumors, five testicular and one ovarian, in relatives of children with bone or soft tissue sarcomas is described. It is proposed that germ cell tumors may be an uncommon manifestation of the genetic predisposition to cancer that exists in the Li-Fraumeni cancer family syndrome.
    • Germ cell tumours confined to the supra-clavicular fossa: a report of two cases.

      Slevin, Nicholas J; James, P D; Morgan, D A (1985-06)
      Two cases of germ cell tumours in males presenting as a left supra-clavicular mass, with no evidence of disease in other sites, are reported. Biopsy showed seminoma in one case and teratoma in the other. Supra-clavicular germ cell tumour as an isolated finding after intensive investigations has not previously been reported.
    • Pelvic haematoma following orchidectomy: a pitfall in the staging of non-seminomatous germ cell tumour.

      Russell, Stephen A; Johnson, Richard J; Russell, J Martin; Department of Diagnostic Radiology, Christie Hospital and Holt Radium Institute, Manchester. (1990-06)
    • Radiotherapy in seminoma of the testis.

      Read, Graham R; Robertson, A Gerald; Blair, Val; Departments of Radiotherapy and Medical Statistics, The Christie Hospital and Holt Radium Institute, Manchester (1983-07)
      Five hundred and forty-seven patients with histologically proven seminoma of the testis were treated by radiotherapy between 1960 and 1978 using a standard method. Of these, 448 patients had 'early' disease and a life-table survival of 94% at 5 years was achieved. Survival was significantly improved in patients treated in later time periods. Survival in more advanced disease was less good (62% in Stage IIB, 51% in Stage III and 13% in Stage IV at 5 years). The radiotherapeutic management of this tumour is discussed.
    • A review of thirty-three cases of ovarian dysgerminoma emphasising the role of radiotherapy.

      Lucraft, Helen H; Christie Hospital and Holt Radium Institute, Manchester (1979-09)
      The records of 33 cases of ovarian dysgerminoma seen in Manchester between 1943 and 1977 are reviewed, including details of presenting features, age distribution, treatment and survival. The five-year survival rate is 85%. All the Stage I cases and all patients under the age of 20 years at presentation have survived. The cases of the five patients who died are analysed in detail. From this series and review of other series it is concluded that young patients with unilateral Stage I desease who have had a total resection should be carefully followed and radiotherapy reserved for recurrent disease. This does not appear to affect their high chance of cure and enable patients who remain disease-free to retain one functioning ovary. All other patients should have surgery followed by radiotherapy to the whole abdomen. Analysis of the five deaths suggested that, even in Stage III disease a surgical attempt should be made to remove the bulk of the tumour and that the abdominal radiotherapy dose should not be less than 3000 rad in 20 treatments in 28 days.
    • Spontaneous pneumothorax with metastatic seminoma.

      Chippindale, A J; Patel, Bella; Eddleston, Brian; Department of Diagnostic Radiology, Christie Hospital, Manchester. (1989-12)
    • Spontaneous regression of metastases from testicular tumours. A report of six cases from one centre.

      Franklin, C I V (1977-09)
      In a review of the cases of testicular tumours treated at the Christie Hospital between 1961 and 1974 there are six cases with spontaneous regression of metastases, which are now reported. In this period, 827 cases of testicular tumour have been treated giving an incidence of spontaneous regression of 0.72%, which is considerably higher than previously reported. One of the cases appears to be pure seminoma; spontaneous regression of metastases from seminoma has not been reported previously.
    • The treatment of advanced seminoma with chemotherapy and radiotherapy.

      Wilkinson, Peter M; Read, G; Magee, Brian; Department of Clinical Pharmacology, Christie Hospital and Holt Radium Institute, Manchester, UK. (1988-01)
      Between 1979 and 1984 thirty-seven patients were treated with combination chemotherapy for metastatic seminoma; 27 of these had relapsed following initial radiotherapy for stage I and IIA disease and 10 patients with stage IIB-IV disease received chemotherapy de novo followed by radiotherapy to sites of bulk disease. Treatment consisted of either a cis-platinum containing combination (25 patients), or cyclophosphamide and etoposide (12 patients). The overall survival of all patients at 5 years was 49%, 34 patients were assessable for response; a CR was obtained in 8 (24%) and a GPR in 19 (56%), the 5 year survival of this group being 66% at 5 years. No difference in survival was seen in relation to age, previous irradiation, serum HCG or LDH; bulk disease however, was an adverse prognostic factor. Survival was similar for both chemotherapy schedules but neutropenia and life-threatening sepsis was less with the cyclophosphamide etoposide combination.
    • The treatment of supradiaphragmatic metastatic seminoma.

      Read, Graham R; Department of Radiotherapy, Christie Hospital, and Holt Radium Institute, Manchester, UK (1980-05)
      Forty-four patients with supradiaphragmatic metastases from seminoma of the testis treated between 1960 and 1973 were studied. Nine patients had metastases at presentation, the remainder developed following abdominal irradiation. Only six patients were long-term survivors, five having nodal disease and one pulmonary parenchymal involvment. Thirty-three patients were treated by whole lung irradiation. The complete remission rate in these cases was poor (55%) despite the use of a dose which gave an appreciable incidence of pulmonary radiation damage. The results are in contrast to the excellent response to treatment obtained with subdiaphragmatic disease.