Browsing All Christie Publications by Authors
Evaluation of NGS and RT-PCR methods for ALK rearrangement in European NSCLC patients: Results from the ETOP Lungscape Project.Letovanec, I; Finn, S; Zygoura, P; Smyth, P; Soltermann, A; Bubendorf, L; Speel, E; Marchetti, A; Nonaka, Daisuke; Monkhorst, K; et al. (2017-11-27)The reported prevalence of ALK rearrangement in NSCLC ranges from 2%-7%. The primary standard diagnostic method is fluorescence in situ hybridization (FISH). Recently, immunohistochemistry (IHC) has also proven to be a reproducible and sensitive technique. Reverse transcriptase-polymerase chain reaction (RT-PCR) has also been advocated and most recently the advent of targeted Next-Generation Sequencing (NGS) for ALK and other fusions has become possible. This study compares ALK evaluation with all 4 techniques in resected NSCLC from the large ETOP Lungscape cohort.
Patient-reported outcomes (PROs) with durvalumab by PD-L1 expression in unresectable, stage III NSCLC (PACIFIC)Garassino, MC; Paz-Ares, L; Hui, R; Faivre-Finn, Corinne; Spira, A; Planchard, D; Ozguroglu, M; Daniel, DB; Vicente, D; Murakami, S; et al. (2019)