Necitumumab plus pemetrexed and cisplatin as first-line therapy in patients with stage IV non-squamous non-small-cell lung cancer (INSPIRE): an open-label, randomised, controlled phase 3 study.
Authors
Paz-Ares, LMezger, J
Ciuleanu, T
Fischer, J
von Pawel, J
Provencio, M
Kazarnowicz, A
Losonczy, G
de Castro, G
Szczesna, A
Crino, L
Reck, M
Ramlau, R
Ulsperger, E
Schumann, C
Miziara, J
Lessa, Á
Dediu, M
Bálint, B
Depenbrock, H
Soldatenkova, V
Kurek, R
Hirsch, F
Thatcher, Nick
Socinski, M
Affiliation
Instituto de Biomedicina de Sevilla-IBIS (Hospital Virgen del Rocio/Universidad de Sevilla/CSIC), Sevilla, SpainIssue Date
2015-03
Metadata
Show full item recordAbstract
Necitumumab is a second-generation recombinant human immunoglobulin G1 EGFR monoclonal antibody that competitively inhibits ligand binding. We aimed to compare necitumumab plus pemetrexed and cisplatin with pemetrexed and cisplatin alone in patients with previously untreated, stage IV, non-squamous non-small-cell lung cancer (NSCLC).Citation
Necitumumab plus pemetrexed and cisplatin as first-line therapy in patients with stage IV non-squamous non-small-cell lung cancer (INSPIRE): an open-label, randomised, controlled phase 3 study. 2015, 16 (3):328-37 Lancet OncolJournal
The Lancet OncologyDOI
10.1016/S1470-2045(15)70046-XPubMed ID
25701171Type
ArticleLanguage
enISSN
1474-5488ae974a485f413a2113503eed53cd6c53
10.1016/S1470-2045(15)70046-X
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