Authors
Howell, AnthonyAnderson, A
Clarke, Robert B
Duffy, S
Evans, D Gareth R
Garcia-Closas, M
Gescher, A
Key, T
Saxton, J
Harvie, Michelle N
Affiliation
"Genesis Breast Cancer Prevention Centre, University Hospital of South Manchester, Southmoor Road, Wythenshawe M29 9LT, Manchester, UKIssue Date
2014
Metadata
Show full item recordAbstract
Breast cancer is an increasing public health problem. Substantial advances have been made in the treatment of breast cancer, but the introduction of methods to predict women at elevated risk and prevent the disease has been less successful. Here, we summarize recent data on newer approaches to risk prediction, available approaches to prevention, how new approaches may be made, and the difficult problem of using what we already know to prevent breast cancer in populations. During 2012, the Breast Cancer Campaign facilitated a series of workshops, each covering a specialty area of breast cancer to identify gaps in our knowledge. The risk-and-prevention panel involved in this exercise was asked to expand and update its report and review recent relevant peer-reviewed literature. The enlarged position paper presented here highlights the key gaps in risk-and-prevention research that were identified, together with recommendations for action. The panel estimated from the relevant literature that potentially 50% of breast cancer could be prevented in the subgroup of women at high and moderate risk of breast cancer by using current chemoprevention (tamoxifen, raloxifene, exemestane, and anastrozole) and that, in all women, lifestyle measures, including weight control, exercise, and moderating alcohol intake, could reduce breast cancer risk by about 30%. Risk may be estimated by standard models potentially with the addition of, for example, mammographic density and appropriate single-nucleotide polymorphisms. This review expands on four areas: (a) the prediction of breast cancer risk, (b) the evidence for the effectiveness of preventive therapy and lifestyle approaches to prevention, (c) how understanding the biology of the breast may lead to new targets for prevention, and (d) a summary of published guidelines for preventive approaches and measures required for their implementation. We hope that efforts to fill these and other gaps will lead to considerable advances in our efforts to predict risk and prevent breast cancer over the next 10 years.Citation
Risk determination and prevention of breast cancer. 2014, 16 (5):446 Breast Cancer ResJournal
Breast Cancer ResearchDOI
10.1186/s13058-014-0446-2PubMed ID
25467785Type
ArticleLanguage
enISSN
1465-542Xae974a485f413a2113503eed53cd6c53
10.1186/s13058-014-0446-2
Scopus Count
Collections
Related articles
- Prevention of breast cancer in postmenopausal women: approaches to estimating and reducing risk.
- Authors: Cummings SR, Tice JA, Bauer S, Browner WS, Cuzick J, Ziv E, Vogel V, Shepherd J, Vachon C, Smith-Bindman R, Kerlikowske K
- Issue date: 2009 Mar 18
- Chemoprevention of breast cancer. A joint guideline from the Canadian Task Force on Preventive Health Care and the Canadian Breast Cancer Initiative's Steering Committee on Clinical Practice Guidelines for the Care and Treatment of Breast Cancer.
- Authors: Levine M, Moutquin JM, Walton R, Feightner J, Canadian Task Force on Preventive Health Care and the Canadian Breast Cancer Initiative's Steering Committee on Clinical Practice Guidelines for the Care and Treatment of Breast Cancer.
- Issue date: 2001 Jun 12
- Chemoprevention for Breast Cancer.
- Authors: Pruthi S, Heisey RE, Bevers TB
- Issue date: 2015 Oct
- The endocrine prevention of breast cancer.
- Authors: Howell A
- Issue date: 2008 Aug
- [Can breast cancer be prevented?].
- Authors: Vatten LJ
- Issue date: 1991 May 30