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    Phase 1 dose-escalation study of the antiplacental growth factor monoclonal antibody RO5323441 combined with bevacizumab in patients with recurrent glioblastoma.

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    Authors
    Lassen, U
    Chinot, O
    McBain, Catherine A
    Mau-Sørensen, M
    Larsen, V
    Barrie, M
    Roth, P
    Krieter, O
    Wang, K
    Habben, K
    Tessier, J
    Lahr, A
    Weller, M
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    Affiliation
    Department of Oncology, Rigshospitalet, Copenhagen, Denmark
    Issue Date
    2015-02-09
    
    Metadata
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    Abstract
    We conducted a phase 1 dose-escalation study of RO5323441, a novel antiplacental growth factor (PlGF) monoclonal antibody, to establish the recommended dose for use with bevacizumab and to investigate the pharmacokinetics, pharmacodynamics, safety/tolerability, and preliminary clinical efficacy of the combination.
    Citation
    Phase 1 dose-escalation study of the antiplacental growth factor monoclonal antibody RO5323441 combined with bevacizumab in patients with recurrent glioblastoma. 2015: Neuro-oncology
    Journal
    Neuro-oncology
    URI
    http://hdl.handle.net/10541/345296
    DOI
    10.1093/neuonc/nov019
    PubMed ID
    25665807
    Type
    Article
    Language
    en
    ISSN
    1523-5866
    ae974a485f413a2113503eed53cd6c53
    10.1093/neuonc/nov019
    Scopus Count
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