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    Improved overall survival in melanoma with combined dabrafenib and trametinib.

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    Authors
    Robert, C
    Karaszewska, B
    Schachter, J
    Rutkowski, P
    Mackiewicz, A
    Stroiakovski, D
    Lichinitser, M
    Dummer, R
    Grange, F
    Mortier, L
    Chiarion-Sileni, V
    Drucis, K
    Krajsova, I
    Hauschild, A
    Lorigan, Paul C
    Wolter, P
    Long, G
    Flaherty, K
    Nathan, P
    Ribas, A
    Martin, A
    Sun, P
    Crist, W
    Legos, J
    Rubin, S
    Little, S
    Schadendorf, D
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    Affiliation
    Gustave Roussy and INSERM Unité 981, Villejuif-Paris Sud
    Issue Date
    2015-01-01
    
    Metadata
    Show full item record
    Abstract
    The BRAF inhibitors vemurafenib and dabrafenib have shown efficacy as monotherapies in patients with previously untreated metastatic melanoma with BRAF V600E or V600K mutations. Combining dabrafenib and the MEK inhibitor trametinib, as compared with dabrafenib alone, enhanced antitumor activity in this population of patients.
    Citation
    Improved overall survival in melanoma with combined dabrafenib and trametinib. 2015, 372 (1):30-9 N Engl J Med
    Journal
    The New England Journal of Medicine
    URI
    http://hdl.handle.net/10541/345293
    DOI
    10.1056/NEJMoa1412690
    PubMed ID
    25399551
    Type
    Article
    Language
    en
    ISSN
    1533-4406
    ae974a485f413a2113503eed53cd6c53
    10.1056/NEJMoa1412690
    Scopus Count
    Collections
    All Christie Publications

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    • Authors: Grob JJ, Amonkar MM, Karaszewska B, Schachter J, Dummer R, Mackiewicz A, Stroyakovskiy D, Drucis K, Grange F, Chiarion-Sileni V, Rutkowski P, Lichinitser M, Levchenko E, Wolter P, Hauschild A, Long GV, Nathan P, Ribas A, Flaherty K, Sun P, Legos JJ, McDowell DO, Mookerjee B, Schadendorf D, Robert C
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