Improved overall survival in melanoma with combined dabrafenib and trametinib.
Authors
Robert, CKaraszewska, B
Schachter, J
Rutkowski, P
Mackiewicz, A
Stroiakovski, D
Lichinitser, M
Dummer, R
Grange, F
Mortier, L
Chiarion-Sileni, V
Drucis, K
Krajsova, I
Hauschild, A
Lorigan, Paul C
Wolter, P
Long, G
Flaherty, K
Nathan, P
Ribas, A
Martin, A
Sun, P
Crist, W
Legos, J
Rubin, S
Little, S
Schadendorf, D
Affiliation
Gustave Roussy and INSERM Unité 981, Villejuif-Paris SudIssue Date
2015-01-01
Metadata
Show full item recordAbstract
The BRAF inhibitors vemurafenib and dabrafenib have shown efficacy as monotherapies in patients with previously untreated metastatic melanoma with BRAF V600E or V600K mutations. Combining dabrafenib and the MEK inhibitor trametinib, as compared with dabrafenib alone, enhanced antitumor activity in this population of patients.Citation
Improved overall survival in melanoma with combined dabrafenib and trametinib. 2015, 372 (1):30-9 N Engl J MedJournal
The New England Journal of MedicineDOI
10.1056/NEJMoa1412690PubMed ID
25399551Type
ArticleLanguage
enISSN
1533-4406ae974a485f413a2113503eed53cd6c53
10.1056/NEJMoa1412690
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