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dc.contributor.authorLevine, Edwarden
dc.contributor.authorMagee, Brianen
dc.contributor.authorDavidson, Susan Een
dc.contributor.authorSwindell, Ricen
dc.contributor.authorHunter, Robin Den
dc.date.accessioned2015-01-15T09:56:30Z
dc.date.available2015-01-15T09:56:30Z
dc.date.issued1995-01
dc.identifier.citationAnalysis of carcinoma of the endometrium treated with post operative radiotherapy. 1995, 6 (1):265-9 Int J Oncolen
dc.identifier.issn1019-6439
dc.identifier.pmid21556533
dc.identifier.urihttp://hdl.handle.net/10541/338270
dc.description.abstractAn audit was carried out of post-operative radiotherapy given for carcinoma of the endometrium at the Christie Hospital between the years of 1984-86. 139 patients were treated following total abdominal hysterectomy (TAH) and bilateral salpingo-oophorectomy (BSO). 54 patients were treated with vaginal brachytherapy alone, 55 had pelvic brick external beam irradiation and 30 patients had both external beam irradiation and vaginal brachytherapy. Overall survival was 84% at 5 years, with a 5.8% local recurrence rate. Histological grade was a prognostic factor for survival (p=0.023) and relapse (p=0.002). Tumour stage was a significant prognostic factor for survival (p=0.011), but not relapse. Survival for stage IB disease was 100% at 5 years with no local recurrence. Major treatment related morbidity was 1.4%, overall; for vaginal brachytherapy alone 0%; for external beam therapy 2%; and combined therapy 3%. Given their good prognosis, and the small but definite risk of major morbidity, patients with stage IB disease may not need postoperative external beam irradiation.
dc.language.isoenen
dc.rightsArchived with thanks to International journal of oncologyen
dc.titleAnalysis of carcinoma of the endometrium treated with post operative radiotherapy.en
dc.typeArticleen
dc.contributor.departmentChristie Hospital, Wilmslow Road, Manchesteren
dc.identifier.journalInternational Journal of Oncologyen
html.description.abstractAn audit was carried out of post-operative radiotherapy given for carcinoma of the endometrium at the Christie Hospital between the years of 1984-86. 139 patients were treated following total abdominal hysterectomy (TAH) and bilateral salpingo-oophorectomy (BSO). 54 patients were treated with vaginal brachytherapy alone, 55 had pelvic brick external beam irradiation and 30 patients had both external beam irradiation and vaginal brachytherapy. Overall survival was 84% at 5 years, with a 5.8% local recurrence rate. Histological grade was a prognostic factor for survival (p=0.023) and relapse (p=0.002). Tumour stage was a significant prognostic factor for survival (p=0.011), but not relapse. Survival for stage IB disease was 100% at 5 years with no local recurrence. Major treatment related morbidity was 1.4%, overall; for vaginal brachytherapy alone 0%; for external beam therapy 2%; and combined therapy 3%. Given their good prognosis, and the small but definite risk of major morbidity, patients with stage IB disease may not need postoperative external beam irradiation.


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