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    Sulphated proteoglycan is required for collecting duct growth and branching but not nephron formation during kidney development.

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    Authors
    Davies, J
    Lyon, Malcolm
    Gallagher, John T
    Garrod, D
    Affiliation
    Cancer Research Campaign Epithelial Morphogenesis Research Group, School of Biological Sciences, University of Manchester, UK.
    Issue Date
    1995-05
    
    Metadata
    Show full item record
    Abstract
    Kidney epithelia have separate origins; collecting ducts develop by ureteric bud growth and arborisation, nephrons by induced mesenchyme-epithelium transition. Both express sulphated glycosaminoglycans (GAGs) which are strikingly upregulated during nephron differentiation. However, sodium chlorate, an inhibitor of GAG sulphation, and the GAG-degrading enzymes heparitinase plus chondroitinase, did not prevent nephron development. In contrast, ureteric bud growth and branching were reversibly inhibited by the above reagents, the inhibition correlating quantitatively with sulphated GAG deprivation caused by a range of chlorate concentrations. Growth and branching could be independently restored during GAG deprivation by hepatocyte growth factor and phorbol-12-myristate acetate (PMA) respectively. Together these signalling effectors stimulated both branch initiation and growth. Thus growth and morphogenesis of ureteric bud involve distinct signalling pathways both regulated by GAGs.
    Citation
    Sulphated proteoglycan is required for collecting duct growth and branching but not nephron formation during kidney development. 1995, 121 (5):1507-17 Development
    Journal
    Development
    URI
    http://hdl.handle.net/10541/338269
    PubMed ID
    7789280
    Type
    Article
    Language
    en
    ISSN
    0950-1991
    Collections
    All Paterson Institute for Cancer Research

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