Efficacy and safety of radium-223 dichloride in patients with castration-resistant prostate cancer and symptomatic bone metastases, with or without previous docetaxel use: a prespecified subgroup analysis from the randomised, double-blind, phase 3 ALSYMPCA trial.
Authors
Hoskin, PSartor, O
O'Sullivan, J
Johannessen, D
Helle, S
Logue, John P
Bottomley, D
Nilsson, S
Vogelzang, N
Fang, F
Wahba, M
Aksnes, A
Parker, C
Affiliation
Mount Vernon Cancer Centre, Northwood, Middlesex, UKIssue Date
2014-11
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Primary results from the phase 3 ALSYMPCA trial showed that radium-223 dichloride (radium-223), a targeted α-emitter, improved overall survival compared with placebo and was well tolerated in patients with castration-resistant prostate cancer and symptomatic bone metastases. We did a prespecified subgroup analysis from ALSYMPCA to assess the effect of previous docetaxel use on the efficacy and safety of radium-223.Citation
Efficacy and safety of radium-223 dichloride in patients with castration-resistant prostate cancer and symptomatic bone metastases, with or without previous docetaxel use: a prespecified subgroup analysis from the randomised, double-blind, phase 3 ALSYMPCA trial. 2014, 15 (12):1397-406 Lancet OncolJournal
The Lancet OncologyDOI
10.1016/S1470-2045(14)70474-7PubMed ID
25439694Type
ArticleLanguage
enISSN
1474-5488ae974a485f413a2113503eed53cd6c53
10.1016/S1470-2045(14)70474-7
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