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dc.contributor.authorKinsella, Anne R
dc.contributor.authorGainer, Helen St C
dc.contributor.authorButler, John
dc.date.accessioned2015-01-08T10:42:30Z
dc.date.available2015-01-08T10:42:30Z
dc.date.issued1983
dc.identifier.citationInvestigation of a possible role for superoxide anion production in tumour promotion. 1983, 4 (6):717-9 Carcinogenesisen
dc.identifier.issn0143-3334
dc.identifier.pmid6305527
dc.identifier.urihttp://hdl.handle.net/10541/337929
dc.description.abstractThe effect of the tumour promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) on superoxide (O-.2) production and superoxide dismutase (SOD) levels has been investigated in human leukocytes and human and rodent fibroblast cell lines. Both O-.2 production and a lowering of the SOD levels were observed in the human leukocytes, but these changes could not be correlated with the induction of gross chromosomal aberrations by TPA. Similarly the use of an O-.2-generating system failed to induce chromosome aberrations. However, a small percentage increase in chromosome aberrations was observed in human fibroblasts after repeated and prolonged exposure to TPA. TPA was shown to reduce the SOD levels in these cells. Overall however, the data suggest that the chromosomes are not the primary site of action for the superoxide anions produced by TPA.
dc.language.isoenen
dc.rightsArchived with thanks to Carcinogenesisen
dc.subject.meshAnimals
dc.subject.meshCricetinae
dc.subject.meshCricetulus
dc.subject.meshHumans
dc.subject.meshLeukocytes
dc.subject.meshLung
dc.subject.meshOxygen
dc.subject.meshPhorbols
dc.subject.meshRats
dc.subject.meshSuperoxide Dismutase
dc.subject.meshSuperoxides
dc.subject.meshTetradecanoylphorbol Acetate
dc.titleInvestigation of a possible role for superoxide anion production in tumour promotion.en
dc.typeArticleen
dc.contributor.departmentPaterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester UKen
dc.identifier.journalCarcinogenesisen
html.description.abstractThe effect of the tumour promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) on superoxide (O-.2) production and superoxide dismutase (SOD) levels has been investigated in human leukocytes and human and rodent fibroblast cell lines. Both O-.2 production and a lowering of the SOD levels were observed in the human leukocytes, but these changes could not be correlated with the induction of gross chromosomal aberrations by TPA. Similarly the use of an O-.2-generating system failed to induce chromosome aberrations. However, a small percentage increase in chromosome aberrations was observed in human fibroblasts after repeated and prolonged exposure to TPA. TPA was shown to reduce the SOD levels in these cells. Overall however, the data suggest that the chromosomes are not the primary site of action for the superoxide anions produced by TPA.


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