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    Investigation of a possible role for superoxide anion production in tumour promotion.

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    Authors
    Kinsella, Anne R
    Gainer, Helen St C
    Butler, John
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester UK
    Issue Date
    1983
    
    Metadata
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    Abstract
    The effect of the tumour promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) on superoxide (O-.2) production and superoxide dismutase (SOD) levels has been investigated in human leukocytes and human and rodent fibroblast cell lines. Both O-.2 production and a lowering of the SOD levels were observed in the human leukocytes, but these changes could not be correlated with the induction of gross chromosomal aberrations by TPA. Similarly the use of an O-.2-generating system failed to induce chromosome aberrations. However, a small percentage increase in chromosome aberrations was observed in human fibroblasts after repeated and prolonged exposure to TPA. TPA was shown to reduce the SOD levels in these cells. Overall however, the data suggest that the chromosomes are not the primary site of action for the superoxide anions produced by TPA.
    Citation
    Investigation of a possible role for superoxide anion production in tumour promotion. 1983, 4 (6):717-9 Carcinogenesis
    Journal
    Carcinogenesis
    URI
    http://hdl.handle.net/10541/337929
    PubMed ID
    6305527
    Type
    Article
    Language
    en
    ISSN
    0143-3334
    Collections
    All Paterson Institute for Cancer Research

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