Show simple item record

dc.contributor.authorLand, Edward Jen
dc.contributor.authorMukherjee, Tulsien
dc.contributor.authorSwallow, A Johnen
dc.contributor.authorBruce, J Men
dc.date.accessioned2015-01-08T11:06:41Z
dc.date.available2015-01-08T11:06:41Z
dc.date.issued1983-08
dc.identifier.citationOne-electron reduction of adriamycin: properties of the semiquinone. 1983, 225 (1):116-21 Arch Biochem Biophysen
dc.identifier.issn0003-9861
dc.identifier.pmid6614911
dc.identifier.urihttp://hdl.handle.net/10541/337925
dc.description.abstractPulse radiolysis of aqueous solutions containing adriamycin and redox indicators of known one-electron reduction potential (E1) shows that its E1 at pH 7 is -328 mV (vs NHE). The variation E1 with pH in the range 6-12 shows that the net charge on the semiquinone at pH 7 is zero. As well as the pKa values of 2.9 and greater than or equal to 14 established independently, the semiquinone has a pKa close to 9.2. The new data enable the structure and likely reactivity of the semiquinone to be specified.
dc.language.isoenen
dc.rightsArchived with thanks to Archives of biochemistry and biophysicsen
dc.subject.meshBenzoquinones
dc.subject.meshChemical Phenomena
dc.subject.meshChemistry
dc.subject.meshDoxorubicin
dc.subject.meshElectrons
dc.subject.meshMathematics
dc.subject.meshModels, Chemical
dc.subject.meshOxidation-Reduction
dc.subject.meshQuinones
dc.titleOne-electron reduction of adriamycin: properties of the semiquinone.en
dc.typeArticleen
dc.contributor.departmentPaterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester M20 9BXen
dc.identifier.journalArchives of Biochemistry and Biophysicsen
html.description.abstractPulse radiolysis of aqueous solutions containing adriamycin and redox indicators of known one-electron reduction potential (E1) shows that its E1 at pH 7 is -328 mV (vs NHE). The variation E1 with pH in the range 6-12 shows that the net charge on the semiquinone at pH 7 is zero. As well as the pKa values of 2.9 and greater than or equal to 14 established independently, the semiquinone has a pKa close to 9.2. The new data enable the structure and likely reactivity of the semiquinone to be specified.


This item appears in the following Collection(s)

Show simple item record