• Login
    View Item 
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Lymphocyte migration into three-dimensional collagen matrices: a quantitative study.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Schor, Seth L
    Allen, Terence D
    Winn, B
    Affiliation
    CRC Department of Medical Oncology, Christie Hospital and Holt Radium Institute, Manchester M20 9BX
    Issue Date
    1983-04
    
    Metadata
    Show full item record
    Abstract
    Lymphocytes have been plated onto the surface of three-dimensional gels of native collagen fibers, and their distribution throughout the three-dimensional collagen matrix has been determined in a quantitative fashion at various times thereafter. Information regarding the total number of applied cells may be obtained by this means. Lymphocyte penetration into the collagen gel does not appear to involve the expression of collagenolytic activity, nor does it require the presence of serum. Analysis of the kinetics of lymphocyte penetration into the gel matrix indicates that lymphocytes are migrating in a "random-walk" fashion. Our objective has been to establish a model system for studying the cell-matrix and cell-cell interactions which influence the pattern of lymphocyte recirculation in vivo and the results presented here are discussed in this context.
    Citation
    Lymphocyte migration into three-dimensional collagen matrices: a quantitative study. 1983, 96 (4):1089-96 J Cell Biol
    Journal
    Journal of Cell Biology
    URI
    http://hdl.handle.net/10541/337912
    PubMed ID
    6833393
    Type
    Article
    Language
    en
    ISSN
    0021-9525
    Collections
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • Cell migration through three-dimensional gels of native collagen fibres: collagenolytic activity is not required for the migration of two permanent cell lines.
    • Authors: Schor SL, Allen TD, Harrison CJ
    • Issue date: 1980 Dec
    • CD4+ T lymphocytes migrating in three-dimensional collagen lattices lack focal adhesions and utilize beta1 integrin-independent strategies for polarization, interaction with collagen fibers and locomotion.
    • Authors: Friedl P, Entschladen F, Conrad C, Niggemann B, Zänker KS
    • Issue date: 1998 Aug
    • Human leucocyte migration through collagen matrices containing other extracellular matrix components.
    • Authors: Reid GG, Newman I
    • Issue date: 1991 Aug
    • Lymphocyte locomotion and attachment on two-dimensional surfaces and in three-dimensional matrices.
    • Authors: Haston WS, Shields JM, Wilkinson PC
    • Issue date: 1982 Mar
    • T lymphocyte infiltration of two- and three-dimensional collagen substrata by an adhesive mechanism.
    • Authors: Sundqvist KG, Hauzenberger D, Hultenby K, Bergström SE
    • Issue date: 1993 May
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.