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Analysis of spontaneous, carcinogen-induced and promoter-induced chromosomal instability in patients with hereditary retinoblastoma.

dc.contributor.authorGainer, H S
dc.contributor.authorKinsella, Anne R
dc.date.accessioned2015-01-08T10:30:27Z
dc.date.available2015-01-08T10:30:27Z
dc.date.issued1983-10-15
dc.identifier.citationAnalysis of spontaneous, carcinogen-induced and promoter-induced chromosomal instability in patients with hereditary retinoblastoma. 1983, 32 (4):449-53 Int J Canceren
dc.identifier.issn0020-7136
dc.identifier.pmid6618708
dc.identifier.urihttp://hdl.handle.net/10541/337886
dc.description.abstractSkin fibroblasts from patients with hereditary retinoblastoma (RB cells) were examined since predisposition to the tumour might be expected to involve some degree of chromosomal instability, as has been noted for several cancer-prone conditions. Spontaneous and N-Methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced aberration frequencies were measured, the cytogenetic effects of long-term treatment with 12-O-tetradecanoyl-phorbol-13acetate (TPA) were examined and also the spontaneous and TPA-induced sister chromatid exchange (SCE) frequencies. In all the studies the RB cells behaved in a similar fashion to normal human skin fibroblasts.
dc.language.isoenen
dc.rightsArchived with thanks to International journal of cancer. Journal international du canceren
dc.subject.meshCells, Cultured
dc.subject.meshChromosome Aberrations
dc.subject.meshChromosome Deletion
dc.subject.meshEye Neoplasms
dc.subject.meshHumans
dc.subject.meshMethylnitronitrosoguanidine
dc.subject.meshPloidies
dc.subject.meshRetinoblastoma
dc.subject.meshSister Chromatid Exchange
dc.subject.meshSkin
dc.subject.meshTetradecanoylphorbol Acetate
dc.subject.meshTime Factors
dc.titleAnalysis of spontaneous, carcinogen-induced and promoter-induced chromosomal instability in patients with hereditary retinoblastoma.en
dc.typeArticleen
dc.contributor.departmentPaterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester M20 9BXen
dc.identifier.journalInternational Journal of Canceren
html.description.abstractSkin fibroblasts from patients with hereditary retinoblastoma (RB cells) were examined since predisposition to the tumour might be expected to involve some degree of chromosomal instability, as has been noted for several cancer-prone conditions. Spontaneous and N-Methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced aberration frequencies were measured, the cytogenetic effects of long-term treatment with 12-O-tetradecanoyl-phorbol-13acetate (TPA) were examined and also the spontaneous and TPA-induced sister chromatid exchange (SCE) frequencies. In all the studies the RB cells behaved in a similar fashion to normal human skin fibroblasts.


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