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    The relationship between antibody concentration and target cell number in the induction of K cell-mediated haemolysis: evidence for asymmetry among reactants.

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    Authors
    Bakács, T
    Ringwald, G
    Tótpál, K
    Kimber, I
    Moore, Michael
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester M20 9BX
    Issue Date
    1983-08
    
    Metadata
    Show full item record
    Abstract
    The cytotoxic capacity of peripheral blood mononuclear cells for anti-D sensitized human O Rh(D) + ve (R1R2) erythrocytes was measured under conditions where antibody concentrations and target cell number were varied with respect to each other. It was observed that where sensitization was limiting, due either to target cell excess or increased antibody dilution, the relationship between lysis and antibody concentration was non-linear, and that the end-point dilution of anti-D at which measurable cytotoxicity occurred was dependent upon the source or concentration of effector cells. The asymmetrical relationship between cytotoxic activity and the degree of sensitization suggests that, in this system at least, there is extensive heterogeneity either among target erythrocytes in terms of their degree of sensitization and consequent susceptibility to lysis, and/or among effector cells in terms of their sensitization requirements for induction of cytotoxicity.
    Citation
    The relationship between antibody concentration and target cell number in the induction of K cell-mediated haemolysis: evidence for asymmetry among reactants. 1983, 11 (4):189-95 J Clin Lab Immunol
    Journal
    Journal of Clinical & Laboratory Immunology
    URI
    http://hdl.handle.net/10541/337727
    PubMed ID
    6321739
    Type
    Article
    Language
    en
    ISSN
    0141-2760
    Collections
    All Paterson Institute for Cancer Research

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