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    The incorporation of O6-methyldeoxyguanosine and O4-methyldeoxythymidine monophosphates into DNA by DNA polymerases I and alpha.

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    Authors
    Hall, Janet A
    Saffhill, Roy
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester M20 9BX
    Issue Date
    1983-06-25
    
    Metadata
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    Abstract
    The modified nucleoside 5'-triphosphates O6-MedGTP ad O4-MedTTP have been synthesised and their acceptability as DNA-precursors investigated using DNA polymerases I and alpha in an in vitro assay. O6-MedGMP is only incorporated into newly-synthesized DNA-like material in the presence of templates containing thymine bases. Similarly O4-MedTMP is only incorporated in the presence of templates containing guanine bases. The results confirm the promutagenic nature and base-pairing properties of O6-MeG ad O4-MeT.
    Citation
    The incorporation of O6-methyldeoxyguanosine and O4-methyldeoxythymidine monophosphates into DNA by DNA polymerases I and alpha. 1983, 11 (12):4185-93 Nucleic Acids Res
    Journal
    Nucleic Acids Research
    URI
    http://hdl.handle.net/10541/337726
    PubMed ID
    6866769
    Type
    Article
    Language
    en
    ISSN
    0305-1048
    Collections
    All Paterson Institute for Cancer Research

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