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    The response of stromal progenitor cells in mouse marrow to graded repeated doses of X rays or neutrons.

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    Authors
    Xu, Cheng Xiong
    Hendry, Jolyon H
    Testa, Nydia G
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester M20 9BX
    Issue Date
    1983-10
    
    Metadata
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    Abstract
    After four repeated doses of 1.5 Gy X rays to mice (3-week intervals), the number of colonies containing fibroblasts that could be grown in vitro from femoral marrow recovered to control numbers by 80 days. After four higher doses, recovery was incomplete, and after four doses of 4.5 Gy, the number was half of the control level up to 1 year after irradiation. After four doses of 14.7 MeV neutrons, no threshold was detected for this late effect, and the RBE was about 2 at 4.5 Gy X rays and about 6 at 1.5 Gy X rays. The RBE for the acute effect on the stromal progenitor cells was also about 2 at 4.5 Gy X rays. The stromal progenitor cells could not be spared relative to hemopoietic stem cells (CFU-S) after neutrons, in contrast to the sparing observed after low-dose fractions of X rays. Experiments with local X irradiations of the leg, and with subcutaneous transplants of femora, revealed no significant recovery of stromal progenitor cells due to migration. However, recovery in situ could be enhanced slightly by marrow grafts i.v.
    Citation
    The response of stromal progenitor cells in mouse marrow to graded repeated doses of X rays or neutrons. 1983, 96 (1):82-9 Radiat Res
    Journal
    Radiation Research
    URI
    http://hdl.handle.net/10541/337725
    PubMed ID
    6622657
    Type
    Article
    Language
    en
    ISSN
    0033-7587
    Collections
    All Paterson Institute for Cancer Research

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