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DNA-DNA interstrand crosslinking by dimethyanesulphonic acid esters. Correlation with cytotoxicity and antitumour activity in the Yoshida lymphosarcoma model and relationship to chain length.

dc.contributor.authorBedford, Philip
dc.contributor.authorFox, Brian W
dc.date.accessioned2014-12-23T14:59:24Z
dc.date.available2014-12-23T14:59:24Z
dc.date.issued1983-08-01
dc.identifier.citationDNA-DNA interstrand crosslinking by dimethyanesulphonic acid esters. Correlation with cytotoxicity and antitumour activity in the Yoshida lymphosarcoma model and relationship to chain length. 1983, 32 (15):2297-301 Biochem Pharmacolen
dc.identifier.issn0006-2952
dc.identifier.pmid6309190
dc.identifier.doi10.1016/0006-2952(83)90176-4
dc.identifier.urihttp://hdl.handle.net/10541/337610
dc.description.abstractMembers of the homologous series of nine antitumour dimethanesulphonic acid esters, with the exception of ethylene dimethanesulphonate (EDMS), were found to cause DNA-DNA interstrand crosslinking in cells derived from the transplantable rodent Yoshida lymphosarcoma. The ability of the series to induce interstrand crosslinks was compared with in vitro cytotoxicity and in vivo antitumour activity and is discussed in relation to their chain length and ability to span critical target distances in DNA.
dc.language.isoenen
dc.rightsArchived with thanks to Biochemical pharmacologyen
dc.subject.meshAnimals
dc.subject.meshAntineoplastic Agents
dc.subject.meshCell Survival
dc.subject.meshCross-Linking Reagents
dc.subject.meshDNA
dc.subject.meshFemale
dc.subject.meshMesylates
dc.subject.meshRats
dc.subject.meshSarcoma, Yoshida
dc.subject.meshStructure-Activity Relationship
dc.titleDNA-DNA interstrand crosslinking by dimethyanesulphonic acid esters. Correlation with cytotoxicity and antitumour activity in the Yoshida lymphosarcoma model and relationship to chain length.en
dc.typeArticleen
dc.contributor.departmentPaterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester M20 9BXen
dc.identifier.journalBiochemical Pharmacologyen
html.description.abstractMembers of the homologous series of nine antitumour dimethanesulphonic acid esters, with the exception of ethylene dimethanesulphonate (EDMS), were found to cause DNA-DNA interstrand crosslinking in cells derived from the transplantable rodent Yoshida lymphosarcoma. The ability of the series to induce interstrand crosslinks was compared with in vitro cytotoxicity and in vivo antitumour activity and is discussed in relation to their chain length and ability to span critical target distances in DNA.


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