DNA-DNA interstrand crosslinking by dimethyanesulphonic acid esters. Correlation with cytotoxicity and antitumour activity in the Yoshida lymphosarcoma model and relationship to chain length.
Affiliation
Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester M20 9BXIssue Date
1983-08-01
Metadata
Show full item recordAbstract
Members of the homologous series of nine antitumour dimethanesulphonic acid esters, with the exception of ethylene dimethanesulphonate (EDMS), were found to cause DNA-DNA interstrand crosslinking in cells derived from the transplantable rodent Yoshida lymphosarcoma. The ability of the series to induce interstrand crosslinks was compared with in vitro cytotoxicity and in vivo antitumour activity and is discussed in relation to their chain length and ability to span critical target distances in DNA.Citation
DNA-DNA interstrand crosslinking by dimethyanesulphonic acid esters. Correlation with cytotoxicity and antitumour activity in the Yoshida lymphosarcoma model and relationship to chain length. 1983, 32 (15):2297-301 Biochem PharmacolJournal
Biochemical PharmacologyDOI
10.1016/0006-2952(83)90176-4PubMed ID
6309190Type
ArticleLanguage
enISSN
0006-2952ae974a485f413a2113503eed53cd6c53
10.1016/0006-2952(83)90176-4