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dc.contributor.authorGarland, John M
dc.contributor.authorCrompton, S
dc.date.accessioned2014-12-23T13:28:17Z
dc.date.available2014-12-23T13:28:17Z
dc.date.issued1983-09
dc.identifier.citationA preliminary report: preparations containing Interleukin-3 (IL-3) promote proliferation of multipotential stem cells (CFUs) in the mouse. 1983, 11 (8):757-61 Exp Hematolen
dc.identifier.issn0301-472X
dc.identifier.pmid6414839
dc.identifier.urihttp://hdl.handle.net/10541/337583
dc.description.abstractThe effect of a preparation containing the lymphokine "Interleukin-3" (IL-3) on murine marrow CFUs has been investigated. When marrow cells are incubated for a short period with IL-3 in vitro, the number of spleen colonies that develop upon injection into irradiated recipients is increased. In addition, an increase is seen in the proportion of CFUs killed in vitro by tritiated thymidine. IL-3 does not affect the seeding efficiency of CFUs in the spleen, but appears to act directly on them, not through production of an endogenous marrow stimulator.
dc.language.isoenen
dc.rightsArchived with thanks to Experimental hematologyen
dc.subject.meshAnimals
dc.subject.meshBone Marrow Cells
dc.subject.meshCell Cycle
dc.subject.meshColony-Forming Units Assay
dc.subject.meshCulture Media
dc.subject.meshHematopoiesis
dc.subject.meshHematopoietic Stem Cells
dc.subject.meshInterleukin-3
dc.subject.meshLymphokines
dc.subject.meshMice
dc.subject.meshMice, Nude
dc.subject.meshThymidine
dc.titleA preliminary report: preparations containing Interleukin-3 (IL-3) promote proliferation of multipotential stem cells (CFUs) in the mouse.en
dc.typeArticleen
dc.contributor.departmentPaterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester M20 9BXen
dc.identifier.journalExperimental Hematologyen
html.description.abstractThe effect of a preparation containing the lymphokine "Interleukin-3" (IL-3) on murine marrow CFUs has been investigated. When marrow cells are incubated for a short period with IL-3 in vitro, the number of spleen colonies that develop upon injection into irradiated recipients is increased. In addition, an increase is seen in the proportion of CFUs killed in vitro by tritiated thymidine. IL-3 does not affect the seeding efficiency of CFUs in the spleen, but appears to act directly on them, not through production of an endogenous marrow stimulator.


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