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    A preliminary report: preparations containing Interleukin-3 (IL-3) promote proliferation of multipotential stem cells (CFUs) in the mouse.

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    Authors
    Garland, John M
    Crompton, S
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester M20 9BX
    Issue Date
    1983-09
    
    Metadata
    Show full item record
    Abstract
    The effect of a preparation containing the lymphokine "Interleukin-3" (IL-3) on murine marrow CFUs has been investigated. When marrow cells are incubated for a short period with IL-3 in vitro, the number of spleen colonies that develop upon injection into irradiated recipients is increased. In addition, an increase is seen in the proportion of CFUs killed in vitro by tritiated thymidine. IL-3 does not affect the seeding efficiency of CFUs in the spleen, but appears to act directly on them, not through production of an endogenous marrow stimulator.
    Citation
    A preliminary report: preparations containing Interleukin-3 (IL-3) promote proliferation of multipotential stem cells (CFUs) in the mouse. 1983, 11 (8):757-61 Exp Hematol
    Journal
    Experimental Hematology
    URI
    http://hdl.handle.net/10541/337583
    PubMed ID
    6414839
    Type
    Article
    Language
    en
    ISSN
    0301-472X
    Collections
    All Paterson Institute for Cancer Research

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