AffiliationDepartment of Radiotherapy, The Christie Hospital & Holt Radium Institute, Manchester
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AbstractTwenty-four patients with advanced carcinoma of the male breast have been treated with tamoxifen citrate (Nolvadex). An objective regression rate of 37.5% was obtained, with five complete and four partial responses. In addition, two patients had stabilisation of their disease for 24 months each. Regression of disease was noted in soft-tissue disease, bone and lung metastases. The duration of response ranged from 8 months to 60 months with a mean of 21 months. In view of the singular lack of side-effects and the age group of the patients (mean age 63 years), it is suggested that tamoxifen should be the first line of endocrine therapy before orchidectomy or adrenalectomy.
CitationTamoxifen in the treatment of male breast carcinoma. 1983, 34 (6):625-8 Clin Radiol
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- Issue date: 1980 Oct
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- Authors: Campbell FC, Morgan DA, Bishop HM, Benton FM, Blamey RW, Elston CW, Nicholson RI, Griffiths K
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- Issue date: 1987 Jan 1
- The value of estrogen and progesterone receptor determinations in advanced breast cancer. Estrogen receptor level but not progesterone receptor level correlates with response to tamoxifen.
- Authors: Bezwoda WR, Esser JD, Dansey R, Kessel I, Lange M
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