Carminomycin vs adriamycin in advanced soft tissue sarcomas: an EORTC randomised phase II study.
Authors
Bramwell, Vivien H CMouridsen, H T
Mulder, J H
Somers, R
Van Oosterom, A T
Santoro, A
Thomas, D
Sylvester, R
Markham, D
Affiliation
Cancer Research Campaign, Department of Medical Oncology, Manchester University and Christie Hospital & Holt Radium Institute, Wilmslow Road, MAnchester M20 9BXIssue Date
1983-08
Metadata
Show full item recordAbstract
Eighty-three patients with advanced soft tissue sarcoma who had received no prior chemotherapy entered a randomised phase II study comparing carminomycin (CMM) 20 mg/m2 with adriamycin (ADM) 75 mg/m2, both administered i.v. bolus every 3 weeks. Six patients were ineligible and response could not be evaluated in 6 additional patients. Thirty-eight evaluable patients received ADM and 33 received CMM. There was one complete response to ADM and 10 partial responses, an overall response rate of 29%. CMM showed significantly (P = 0.01) lower antitumour activity--one partial response (3%). Stabilisation of disease was similar in both arms (47 and 45%), but fewer patients progressed on ADM (24 compared to 52%). Durations of response dating from the start of chemotherapy were 5 months for complete remission on ADM, a median of 7 months (range 4-17) for partial response on ADM and 14 months for the one partial remission on CMM. Although the median time to progression for all patients receiving CMM (2 months) was significantly (P = 0.001) shorter than for those receiving ADM (5 months), patients on ADM had only a marginally significant longer duration of survival (P = 0.06) than the patients receiving CMM. A leucocyte nadir less than 2.0 X 10(9)/l occurred in 38% of patients receiving ADM and 43% receiving CMM. Anaemia and thrombocytopoenia were uncommon. Other toxicities such as nausea, vomiting, anorexia and alopecia were more severe in the ADM group. There was one infective death secondary to leucopoenia in the ADM arm, and one patient who had received 109 mg/m2 CMM + 255 mg/m2 ADM developed progressively fatal cardiomyopathy.Citation
Carminomycin vs adriamycin in advanced soft tissue sarcomas: an EORTC randomised phase II study. 1983, 19 (8):1097-104 Eur J Cancer Clin OncolJournal
European Journal of Cancer & Clinical OncologyDOI
10.1016/0277-5379(83)90034-2PubMed ID
6352280Type
ArticleLanguage
enISSN
0277-5379ae974a485f413a2113503eed53cd6c53
10.1016/0277-5379(83)90034-2