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    Native and inducible levels of natural cytotoxicity in lymph nodes draining mammary carcinoma.

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    Authors
    Kimber, I
    Moore, Michael
    Howell, Anthony
    Wilkinson, M J S
    Affiliation
    Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester, M20 9BX
    Issue Date
    1983
    
    Metadata
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    Abstract
    Lymphocytes isolated from axillary nodes draining breast carcinoma possess variable natural cytotoxic capacity. Augmentation of lymph node cell (LNC) cytotoxicity by interferon (IFN) is also variable, with only some populations displaying potentiated lysis following exposure to either IFN-a or gene-cloned IFN-a2. Where present the IFN-induced augmentation of LNC cytotoxicity was invariably weaker than that observed following similar treatment of autochthonous peripheral blood mononuclear cells (PBMC). Irrespective of their responsiveness to IFN the cytotoxic activity of all LNC preparations examined was significantly increased following pre-incubation with either staphylococcal enterotoxin A (SEA) or factors elaborated by lectin-pulsed allogeneic LNC. THe induction or amplification fo LNC-mediated natural cytotoxicity by lymphokines may provide a local potentiation of natural immune function at the host : tumour interface.
    Citation
    Native and inducible levels of natural cytotoxicity in lymph nodes draining mammary carcinoma. 1983, 15 (1):32-8 Cancer Immunol Immunother
    Journal
    Cancer Immunology, Immunotherapy
    URI
    http://hdl.handle.net/10541/337521
    PubMed ID
    6553505
    Type
    Article
    Language
    en
    ISSN
    0340-7004
    Collections
    All Christie Publications

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