Gastrointestinal involvement with myeloma.
dc.contributor.author | Benson, W J | |
dc.contributor.author | Scarffe, J Howard | |
dc.contributor.author | Houwen, B | |
dc.contributor.author | Crowther, Derek | |
dc.date.accessioned | 2014-12-22T15:10:42Z | |
dc.date.available | 2014-12-22T15:10:42Z | |
dc.date.issued | 1983 | |
dc.identifier.citation | Gastrointestinal involvement with myeloma. 1983, 11 (4):256-62 Med Pediatr Oncol | en |
dc.identifier.issn | 0098-1532 | |
dc.identifier.pmid | 6888326 | |
dc.identifier.uri | http://hdl.handle.net/10541/337511 | |
dc.description.abstract | A patient with IgA-k multiple myeloma is presented. There was initially a good response to chemotherapy but the patient later developed small intestinal obstruction. This was due to multiple polypoid plasmacytomas. The mesenteric nodes were also involved, and were found on immunofluorescence microscopy and flow cytometry with double fluorescent labelling to be composed of two separate populations of cells (IgA-k and IgG-k), one population having a diploid content of DNA and the other tetraploid. These two distinct cell populations differed in both proliferative characteristics and size. The findings are discussed and the literature relating to gastrointestinal involvement in plasma cell dyscrasias reviewed. | |
dc.language.iso | en | en |
dc.rights | Archived with thanks to Medical and pediatric oncology | en |
dc.subject.mesh | Bone Marrow | |
dc.subject.mesh | DNA | |
dc.subject.mesh | Flow Cytometry | |
dc.subject.mesh | Gastrointestinal Neoplasms | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Immunoglobulin A | |
dc.subject.mesh | Immunoglobulin G | |
dc.subject.mesh | Lymph Nodes | |
dc.subject.mesh | Male | |
dc.subject.mesh | Middle Aged | |
dc.subject.mesh | Multiple Myeloma | |
dc.title | Gastrointestinal involvement with myeloma. | en |
dc.type | Article | en |
dc.contributor.department | Cancer Research Campaign, Department of Medical Oncology, Christie Hospital and Holt Radium Institute, Manchester | en |
dc.identifier.journal | Medical and Pediatric Oncology | en |
html.description.abstract | A patient with IgA-k multiple myeloma is presented. There was initially a good response to chemotherapy but the patient later developed small intestinal obstruction. This was due to multiple polypoid plasmacytomas. The mesenteric nodes were also involved, and were found on immunofluorescence microscopy and flow cytometry with double fluorescent labelling to be composed of two separate populations of cells (IgA-k and IgG-k), one population having a diploid content of DNA and the other tetraploid. These two distinct cell populations differed in both proliferative characteristics and size. The findings are discussed and the literature relating to gastrointestinal involvement in plasma cell dyscrasias reviewed. |