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dc.contributor.authorBenson, W J
dc.contributor.authorScarffe, J Howard
dc.contributor.authorHouwen, B
dc.contributor.authorCrowther, Derek
dc.date.accessioned2014-12-22T15:10:42Z
dc.date.available2014-12-22T15:10:42Z
dc.date.issued1983
dc.identifier.citationGastrointestinal involvement with myeloma. 1983, 11 (4):256-62 Med Pediatr Oncolen
dc.identifier.issn0098-1532
dc.identifier.pmid6888326
dc.identifier.urihttp://hdl.handle.net/10541/337511
dc.description.abstractA patient with IgA-k multiple myeloma is presented. There was initially a good response to chemotherapy but the patient later developed small intestinal obstruction. This was due to multiple polypoid plasmacytomas. The mesenteric nodes were also involved, and were found on immunofluorescence microscopy and flow cytometry with double fluorescent labelling to be composed of two separate populations of cells (IgA-k and IgG-k), one population having a diploid content of DNA and the other tetraploid. These two distinct cell populations differed in both proliferative characteristics and size. The findings are discussed and the literature relating to gastrointestinal involvement in plasma cell dyscrasias reviewed.
dc.language.isoenen
dc.rightsArchived with thanks to Medical and pediatric oncologyen
dc.subject.meshBone Marrow
dc.subject.meshDNA
dc.subject.meshFlow Cytometry
dc.subject.meshGastrointestinal Neoplasms
dc.subject.meshHumans
dc.subject.meshImmunoglobulin A
dc.subject.meshImmunoglobulin G
dc.subject.meshLymph Nodes
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshMultiple Myeloma
dc.titleGastrointestinal involvement with myeloma.en
dc.typeArticleen
dc.contributor.departmentCancer Research Campaign, Department of Medical Oncology, Christie Hospital and Holt Radium Institute, Manchesteren
dc.identifier.journalMedical and Pediatric Oncologyen
html.description.abstractA patient with IgA-k multiple myeloma is presented. There was initially a good response to chemotherapy but the patient later developed small intestinal obstruction. This was due to multiple polypoid plasmacytomas. The mesenteric nodes were also involved, and were found on immunofluorescence microscopy and flow cytometry with double fluorescent labelling to be composed of two separate populations of cells (IgA-k and IgG-k), one population having a diploid content of DNA and the other tetraploid. These two distinct cell populations differed in both proliferative characteristics and size. The findings are discussed and the literature relating to gastrointestinal involvement in plasma cell dyscrasias reviewed.


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