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    Trilostane in the treatment of advanced breast cancer.

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    Authors
    Beardwell, Colin G
    Hindley, A C
    Wilkinson, Peter M
    Todd, Ian D
    Ribeiro, G
    Bu'Lock, D
    Affiliation
    Christie Hospital and Holt Radium Institute, WIlmslow Rd, Manchester M20 9BX
    Issue Date
    1983
    
    Metadata
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    Abstract
    The combination of trilostane 960 mg daily and either dexamethasone 0.5 mg b.d. or hydrocortisone 10 mg b.d. has been used to treat advanced metastatic breast cancer in post-menopausal women. Twenty-three patients had assessable disease and received treatment for a minimum of 8 weeks. Six (26%) showed an objective response and three (13%), stabilisation of previously progressive disease, sustained for at least 3 months. Side-effects were mainly gastrointestinal. Biochemical studies suggest that the mechanism of action may be inhibition of conversion of androstenedione to oestrone.
    Citation
    Trilostane in the treatment of advanced breast cancer. 1983, 10 (3):158-60 Cancer Chemother Pharmacol
    Journal
    Cancer Chemotherapy and Pharmacology
    URI
    http://hdl.handle.net/10541/336954
    PubMed ID
    6861259
    Type
    Article
    Language
    en
    ISSN
    0344-5704
    Collections
    All Christie Publications

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