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    The meaning, measurement and modification of hypoxia in the laboratory and the clinic.

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    Authors
    Hammond, E M
    Asselin, Marie-Claude
    Forster, D
    O'Connor, James P B
    Senra, J M
    Williams, K J
    Affiliation
    The Gray Institute for Radiation Oncology and Biology, Department of Oncology, University of Oxford, Oxford, UK.
    Issue Date
    2014-05
    
    Metadata
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    Abstract
    Hypoxia was identified as a microenvironmental component of solid tumours over 60 years ago and was immediately recognised as a potential barrier to therapy through the reliance of radiotherapy on oxygen to elicit maximal cytotoxicity. Over the last two decades both clinical and experimental studies have markedly enhanced our understanding of how hypoxia influences cellular behaviour and therapy response. Furthermore, they have confirmed early assumptions that low oxygenation status in tumours is an exploitable target in cancer therapy. Generally such approaches will be more beneficial to patients with hypoxic tumours, necessitating the use of biomarkers that reflect oxygenation status. Tissue biomarkers have shown utility in many studies. Further significant advances have been made in the non-invasive measurement of tumour hypoxia with positron emission tomography, magnetic resonance imaging and other imaging modalities. Here, we describe the complexities of defining and measuring tumour hypoxia and highlight the therapeutic approaches to combat it.
    Citation
    The meaning, measurement and modification of hypoxia in the laboratory and the clinic. 2014, 26 (5):277-88 Clin Oncol
    Journal
    Clinical Oncology
    URI
    http://hdl.handle.net/10541/336224
    DOI
    10.1016/j.clon.2014.02.002
    PubMed ID
    24602562
    Type
    Article
    Language
    en
    ISSN
    1433-2981
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.clon.2014.02.002
    Scopus Count
    Collections
    Manchester Molecular Imaging Centre

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