The meaning, measurement and modification of hypoxia in the laboratory and the clinic.
Affiliation
The Gray Institute for Radiation Oncology and Biology, Department of Oncology, University of Oxford, Oxford, UK.Issue Date
2014-05
Metadata
Show full item recordAbstract
Hypoxia was identified as a microenvironmental component of solid tumours over 60 years ago and was immediately recognised as a potential barrier to therapy through the reliance of radiotherapy on oxygen to elicit maximal cytotoxicity. Over the last two decades both clinical and experimental studies have markedly enhanced our understanding of how hypoxia influences cellular behaviour and therapy response. Furthermore, they have confirmed early assumptions that low oxygenation status in tumours is an exploitable target in cancer therapy. Generally such approaches will be more beneficial to patients with hypoxic tumours, necessitating the use of biomarkers that reflect oxygenation status. Tissue biomarkers have shown utility in many studies. Further significant advances have been made in the non-invasive measurement of tumour hypoxia with positron emission tomography, magnetic resonance imaging and other imaging modalities. Here, we describe the complexities of defining and measuring tumour hypoxia and highlight the therapeutic approaches to combat it.Citation
The meaning, measurement and modification of hypoxia in the laboratory and the clinic. 2014, 26 (5):277-88 Clin OncolJournal
Clinical OncologyDOI
10.1016/j.clon.2014.02.002PubMed ID
24602562Type
ArticleLanguage
enISSN
1433-2981ae974a485f413a2113503eed53cd6c53
10.1016/j.clon.2014.02.002