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    Indications for IVIG in rheumatic diseases.

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    Authors
    Mulhearn, Ben
    Bruce, Iain A
    Affiliation
    Christie NHS Foundation Trust, Manchester, UK
    Issue Date
    2014-11-17
    
    Metadata
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    Abstract
    The use of IVIG to treat a wide variety of immune-driven diseases has grown rapidly, although the mechanism of action is not completely understood. Increasing demand for IVIG coupled with concerns regarding potential transmissible agents has led to worldwide supply shortages. National agencies have therefore produced guidelines for its use, with the latest England and Wales guideline being published in 2011. Due to the rarity of the rheumatic diseases, the evidence for IVIG use has been shown to be lacking in some areas and promising in others. Conditions in which IVIG has been shown to have benefit include ITP, Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy occurring in the context of rheumatic disease, as well as in SLE, idiopathic inflammatory myopathies and ANCA-associated vasculitides. This review looks at current IVIG use and is designed to be an aid for rheumatologists when considering the use of IVIG in clinical practice.
    Citation
    Indications for IVIG in rheumatic diseases. 2014: Rheumatology
    Journal
    Rheumatology
    URI
    http://hdl.handle.net/10541/336214
    DOI
    10.1093/rheumatology/keu429
    PubMed ID
    25406359
    Type
    Article
    Language
    en
    ISSN
    1462-0332
    ae974a485f413a2113503eed53cd6c53
    10.1093/rheumatology/keu429
    Scopus Count
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