Practical management of sunitinib toxicities in the treatment of pancreatic neuroendocrine tumors.
AffiliationUniversity of Manchester, Manchester Health Sciences Centre and Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester M20 4BX, UK.
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AbstractPancreatic neuroendocrine tumors (pNETs) are infrequent malignancies which manifest in both functional (hormone-secreting) and more commonly non-functional (non-secreting) forms. The oral multitargeted tyrosine kinase inhibitor sunitinib and mammalian target of rapamycin (mTOR) inhibitor everolimus are approved as targeted therapies for patients with well-differentiated, non-resectable disease and evidence of disease progression. The recent approval of sunitinib for the management of advanced pNET is based on a continuous daily dosing (CDD) schedule that differs from the intermittent 4weeks on/2weeks off (4/2) schedule approved for sunitinib in advanced renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). Therefore, although clinicians may be familiar with therapy management approaches for sunitinib in advanced RCC and GIST, there is less available experience for the management of patients with a CDD schedule. Here, we discuss the similarities and differences in the treatment of pNET with sunitinib compared with advanced RCC and GIST. In particular, we focus on the occurrence and management of sunitinib-related toxicity in patients with pNET by drawing on experience in these other malignancies. We aim to provide a relevant and useful guide for clinicians treating patients with pNET covering the management of events such as fatigue, mucositis, hand-foot syndrome, and hypertension.
CitationPractical management of sunitinib toxicities in the treatment of pancreatic neuroendocrine tumors. 2014: Cancer Treat Rev
JournalCancer Treatment Reviews
- Benefit-risk assessment of sunitinib in gastrointestinal stromal tumours and renal cancer.
- Authors: Theou-Anton N, Faivre S, Dreyer C, Raymond E
- Issue date: 2009
- FDA approval summary: sunitinib for the treatment of progressive well-differentiated locally advanced or metastatic pancreatic neuroendocrine tumors.
- Authors: Blumenthal GM, Cortazar P, Zhang JJ, Tang S, Sridhara R, Murgo A, Justice R, Pazdur R
- Issue date: 2012
- Sunitinib and everolimus in pancreatic neuroendocrine tumors.
- Authors: Procopio G, Pusceddu S, Buzzoni R
- Issue date: 2012 May-Jun
- Sunitinib: a multitargeted receptor tyrosine kinase inhibitor in the era of molecular cancer therapies.
- Authors: Papaetis GS, Syrigos KN
- Issue date: 2009
- Sunitinib malate for the treatment of pancreatic neuroendocrine tumors.
- Authors: Raymond E, Dahan L, Raoul JL, Bang YJ, Borbath I, Lombard-Bohas C, Valle J, Metrakos P, Smith D, Vinik A, Chen JS, Hörsch D, Hammel P, Wiedenmann B, Van Cutsem E, Patyna S, Lu DR, Blanckmeister C, Chao R, Ruszniewski P
- Issue date: 2011 Feb 10