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    Caveolin-1 regulates the anti-atherogenic properties of macrophages.

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    Authors
    Pavlides, Stephanos
    Gutierrez-Pajares, J
    Katiyar, S
    Jasmin, J
    Mercier, I
    Walters, R
    Pavlides, C
    Pestell, R
    Lisanti, Michael P
    Frank, P
    Affiliation
    Manchester Breast Centre & Breakthrough Breast Cancer Research Unit, Paterson Institute for Cancer Research, School of Cancer, Enabling Sciences and Technology, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
    Issue Date
    2014-10-17
    
    Metadata
    Show full item record
    Abstract
    Atherosclerosis is a complex disease initiated by the vascular accumulation of lipoproteins in the sub-endothelial space, followed by the infiltration of monocytes into the arterial intima. Caveolin-1 (Cav-1) plays an essential role in the regulation of cellular cholesterol metabolism and of various signaling pathways. In order to study specifically the role of macrophage Cav-1 in atherosclerosis, we used Cav-1 (-/-) Apoe (-/-) mice and transplanted them with bone marrow (BM) cells obtained from Cav-1 (+/+) Apoe (-/-) or Cav-1 (-/-) Apoe (-/-) mice and vice versa. We found that Cav-1 (+/+) mice harboring Cav-1 (-/-) BM-derived macrophages developed significantly larger lesions than Cav-1 (+/+) mice harboring Cav-1 (+/+) BM-derived macrophages. Cav-1 (-/-) macrophages were more susceptible to apoptosis and more prone to induce inflammation. The present study provides clear evidence that the absence of Cav-1 in macrophage is pro-atherogenic, whereas its absence in endothelial cells protects against atherosclerotic lesion formation. These findings demonstrate the cell-specific role of Cav-1 during the development of this disease.
    Citation
    Caveolin-1 regulates the anti-atherogenic properties of macrophages. 2014: Cell Tissue Res
    Journal
    Cell and Tissue Research
    URI
    http://hdl.handle.net/10541/333862
    DOI
    10.1007/s00441-014-2008-4
    PubMed ID
    25322709
    Type
    Article
    Language
    en
    ISSN
    1432-0878
    ae974a485f413a2113503eed53cd6c53
    10.1007/s00441-014-2008-4
    Scopus Count
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    All Paterson Institute for Cancer Research

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