Affiliation
Stepping Hill Hospital, Stockport, UK z.karim@doctors.org.uk.Issue Date
2013-11-12
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Show full item recordAbstract
Fibroblastic reticulum cells (FBRCs) belong to a major subtype of stromal support cells in the lymphoid system and rarely give rise to tumors. We report a case of fibroblastic reticulum cell tumor arising in the spleen. The tumor was clinically and radiologically mistaken for a metastatic deposit in the spleen. Microscopically the tumor was composed of spindle cells arranged in fascicles and storiform pattern. The cells had oval to elongated vesicular nuclei and pale eosinophilic cytoplasm with indistinct cell borders. There were admixed inflammatory cells, including large numbers of plasma cells. The tumor cells were positive for smooth muscle actin, desmin, AE1/AE3, and MNF116. They were negative for S100, CD1a, CD21, CD23, CD34, CD31, and CD35 among other markers. The morphological features and immunoprofile of this rare tumor in comparison to the few cases reported in the literature are discussed along with the positive reaction with cytokeratins and their relationship to the smaller subset of FBRCs, the cytokeratin-positive interstitial reticulum cells in the spleen.Citation
Fibroblastic reticulum cell tumor of spleen: a case report. 2013, 22 (5):447-450 Int. J Surg PatholJournal
International Journal of Surgical PathologyDOI
10.1177/1066896913509009PubMed ID
24220998Type
ArticleLanguage
enISSN
1940-2465ae974a485f413a2113503eed53cd6c53
10.1177/1066896913509009
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