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dc.contributor.authorJamal-Hanjani, M
dc.contributor.authorHackshaw, A
dc.contributor.authorNgai, Y
dc.contributor.authorShaw, J
dc.contributor.authorDive, Caroline
dc.contributor.authorQuezada, S
dc.contributor.authorMiddleton, G
dc.contributor.authorde Bruin, E
dc.contributor.authorLe Quesne, J
dc.contributor.authorShafi, S
dc.contributor.authorFalzon, M
dc.contributor.authorHorswell, S
dc.contributor.authorBlackhall, Fiona H
dc.contributor.authorKhan, I
dc.contributor.authorJanes, S
dc.contributor.authorNicolson, M
dc.contributor.authorLawrence, D
dc.contributor.authorForster, M
dc.contributor.authorFennell, D
dc.contributor.authorLee, S
dc.contributor.authorLester, J
dc.contributor.authorKerr, K
dc.contributor.authorMuller, S
dc.contributor.authorIles, N
dc.contributor.authorSmith, S
dc.contributor.authorMurugaesu, N
dc.contributor.authorMitter, R
dc.contributor.authorSalm, M
dc.contributor.authorStuart, A
dc.contributor.authorMatthews, N
dc.contributor.authorAdams, H
dc.contributor.authorAhmad, T
dc.contributor.authorAttanoos, R
dc.contributor.authorBennett, J
dc.contributor.authorBirkbak, N
dc.contributor.authorBooton, R
dc.contributor.authorBrady, G
dc.contributor.authorBuchan, K
dc.contributor.authorCapitano, A
dc.contributor.authorChetty, M
dc.contributor.authorCobbold, M
dc.contributor.authorCrosbie, P
dc.contributor.authorDavies, H
dc.contributor.authorDenison, A
dc.contributor.authorDjearman, M
dc.contributor.authorGoldman, J
dc.contributor.authorHaswell, T
dc.contributor.authorJoseph, L
dc.contributor.authorKornaszewska, M
dc.contributor.authorKrebs, M
dc.contributor.authorLangman, G
dc.contributor.authorMacKenzie, M
dc.contributor.authorMillar, J
dc.contributor.authorMorgan, B
dc.contributor.authorNaidu, B
dc.contributor.authorNonaka, Daisuke
dc.contributor.authorPeggs, K
dc.contributor.authorPritchard, C
dc.contributor.authorRemmen, H
dc.contributor.authorRowan, A
dc.contributor.authorShah, R
dc.contributor.authorSmith, E
dc.contributor.authorSummers, Yvonne J
dc.contributor.authorTaylor, M
dc.contributor.authorVeeriah, S
dc.contributor.authorWaller, D
dc.contributor.authorWilcox, B
dc.contributor.authorWilcox, M
dc.contributor.authorWoolhouse, I
dc.contributor.authorMcGranahan, N
dc.contributor.authorSwanton, C
dc.date.accessioned2014-10-08T10:07:19Z
dc.date.available2014-10-08T10:07:19Z
dc.date.issued2014-07
dc.identifier.citationTracking genomic cancer evolution for precision medicine: the lung TRACERx study. 2014, 12 (7):e1001906 PLoS Biol.en
dc.identifier.issn1545-7885
dc.identifier.pmid25003521
dc.identifier.doi10.1371/journal.pbio.1001906
dc.identifier.urihttp://hdl.handle.net/10541/332333
dc.description.abstractThe importance of intratumour genetic and functional heterogeneity is increasingly recognised as a driver of cancer progression and survival outcome. Understanding how tumour clonal heterogeneity impacts upon therapeutic outcome, however, is still an area of unmet clinical and scientific need. TRACERx (TRAcking non-small cell lung Cancer Evolution through therapy [Rx]), a prospective study of patients with primary non-small cell lung cancer (NSCLC), aims to define the evolutionary trajectories of lung cancer in both space and time through multiregion and longitudinal tumour sampling and genetic analysis. By following cancers from diagnosis to relapse, tracking the evolutionary trajectories of tumours in relation to therapeutic interventions, and determining the impact of clonal heterogeneity on clinical outcomes, TRACERx may help to identify novel therapeutic targets for NSCLC and may also serve as a model applicable to other cancer types.
dc.language.isoenen
dc.rightsArchived with thanks to PLoS biologyen
dc.titleTracking genomic cancer evolution for precision medicine: the lung TRACERx study.en
dc.typeArticleen
dc.contributor.departmentTranslational Cancer Therapeutics Laboratory, University College London Cancer Institute, London, United Kingdom; Department of Medical Oncology, University College London Hospitals, London, United Kingdom.en
dc.identifier.journalPLoS Biologyen
html.description.abstractThe importance of intratumour genetic and functional heterogeneity is increasingly recognised as a driver of cancer progression and survival outcome. Understanding how tumour clonal heterogeneity impacts upon therapeutic outcome, however, is still an area of unmet clinical and scientific need. TRACERx (TRAcking non-small cell lung Cancer Evolution through therapy [Rx]), a prospective study of patients with primary non-small cell lung cancer (NSCLC), aims to define the evolutionary trajectories of lung cancer in both space and time through multiregion and longitudinal tumour sampling and genetic analysis. By following cancers from diagnosis to relapse, tracking the evolutionary trajectories of tumours in relation to therapeutic interventions, and determining the impact of clonal heterogeneity on clinical outcomes, TRACERx may help to identify novel therapeutic targets for NSCLC and may also serve as a model applicable to other cancer types.


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