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    Siltuximab for multicentric Castleman's disease: a randomised, double-blind, placebo-controlled trial.

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    Authors
    van Rhee, F
    Wong, R
    Munshi, N
    Rossi, J
    Ke, X
    Fosså, A
    Simpson, D
    Capra, M
    Liu, T
    Hsieh, R
    Goh, Y
    Zhu, J
    Cho, S
    Ren, H
    Cavet, James
    Bandekar, R
    Rothman, M
    Puchalski, T
    Reddy, M
    van de Velde, H
    Vermeulen, J
    Casper, C
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    Affiliation
    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
    Issue Date
    2014-08
    
    Metadata
    Show full item record
    Abstract
    Multicentric Castleman's disease is a rare lymphoproliferative disorder driven by dysregulated production of interleukin 6. No randomised trials have been done to establish the best treatment for the disease. We assessed the safety and efficacy of siltuximab-a chimeric monoclonal antibody against interleukin 6-in HIV-negative patients with multicentric Castleman's disease.
    Citation
    Siltuximab for multicentric Castleman's disease: a randomised, double-blind, placebo-controlled trial. 2014, 15 (9):966-74 Lancet Oncol
    Journal
    The Lancet Oncology
    URI
    http://hdl.handle.net/10541/325867
    DOI
    10.1016/S1470-2045(14)70319-5
    PubMed ID
    25042199
    Type
    Article
    Language
    en
    ISSN
    1474-5488
    ae974a485f413a2113503eed53cd6c53
    10.1016/S1470-2045(14)70319-5
    Scopus Count
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