Circulating tumor cells as tumor biomarkers in melanoma: detection methods and clinical relevance.
| dc.contributor.author | Khoja, Leila | |
| dc.contributor.author | Lorigan, Paul C | |
| dc.contributor.author | Dive, Caroline | |
| dc.contributor.author | Keilholz, U | |
| dc.contributor.author | Fusi, Alberto | |
| dc.date.accessioned | 2014-08-05T13:57:06Z | |
| dc.date.available | 2014-08-05T13:57:06Z | |
| dc.date.issued | 2014-06-06 | |
| dc.identifier.citation | Circulating tumor cells as tumor biomarkers in melanoma: detection methods and clinical relevance. 2014: Ann Oncol | en |
| dc.identifier.issn | 1569-8041 | |
| dc.identifier.pmid | 24907634 | |
| dc.identifier.doi | 10.1093/annonc/mdu207 | |
| dc.identifier.uri | http://hdl.handle.net/10541/324251 | |
| dc.description.abstract | Circulating tumour cells (CTC) are cells of solid tumor origin detectable in the peripheral blood. Their occurrence is considered a prerequisite step for establishing distant metastases. Metastatic melanoma was the first malignancy in which CTCs were detected and numerous studies have been published on CTC detection in melanoma at various stages of disease. In spite of this there is no general consensus as to the clinical utility of CTCs in melanoma, largely due to conflicting results from heterogeneous studies and discrepancies in methods of detection between studies. In this review, we examine the possible clinical significance of CTCs in cutaneous, mucosal and ocular melanoma, focusing on detection methods and prognostic value of CTC detection. | |
| dc.language | ENG | |
| dc.language.iso | en | en |
| dc.rights | Archived with thanks to Annals of oncology : official journal of the European Society for Medical Oncology / ESMO | en |
| dc.title | Circulating tumor cells as tumor biomarkers in melanoma: detection methods and clinical relevance. | en |
| dc.type | Article | en |
| dc.contributor.department | Department of Medical Oncology, The Christie NHS Foundation Trust, Wilmslow Road, Manchester, UK. | en |
| dc.identifier.journal | Annals of Oncology | en |
| html.description.abstract | Circulating tumour cells (CTC) are cells of solid tumor origin detectable in the peripheral blood. Their occurrence is considered a prerequisite step for establishing distant metastases. Metastatic melanoma was the first malignancy in which CTCs were detected and numerous studies have been published on CTC detection in melanoma at various stages of disease. In spite of this there is no general consensus as to the clinical utility of CTCs in melanoma, largely due to conflicting results from heterogeneous studies and discrepancies in methods of detection between studies. In this review, we examine the possible clinical significance of CTCs in cutaneous, mucosal and ocular melanoma, focusing on detection methods and prognostic value of CTC detection. |