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    CT scan does not predict optimal debulking in stage III-IV epithelial ovarian cancer: a multicentre validation study.

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    Authors
    MacKintosh, M
    Rahim, R
    Rajashanker, B
    Swindell, Ric
    Kirmani, B
    Hunt, J
    Brockbank, E
    Barton, D
    Clayton, R
    Affiliation
    Department of Gynaecological Oncology, Central Manchester Foundation Trust , Manchester , UK.
    Issue Date
    2014-07
    
    Metadata
    Show full item record
    Abstract
    Our aim was to design and validate a model of CT findings that predict suboptimal cytoreduction in primary surgery (PS) for Stage III-IV epithelial ovarian cancer (EOC). We performed a retrospective review of preoperative CT scans of patients undergoing PS for EOC in a cancer centre in London, UK, between November 1995 and October 2003 (n = 91). Radiological features predictive of suboptimal cytoreduction were identified and the model tested in a second cohort undergoing PS in Manchester, June 2005 - March 2007 (n = 35). In the London cohort, liver surface disease and infrarenal para-aortic lymph node involvement predicted suboptimal cytoreduction with 80% accuracy. Accuracy of these predictors dropped to 63% when applied to the Manchester cohort. We concluded that CT prediction of suboptimal cytoreduction is unreliable and may not be reproducible. In the absence of favourable data from larger, prospective trials, it should not be used to guide management.
    Citation
    CT scan does not predict optimal debulking in stage III-IV epithelial ovarian cancer: a multicentre validation study. 2014, 34 (5):424-8 J Obstet Gynaecol
    Journal
    Journal of Obstetrics and Gynaecology
    URI
    http://hdl.handle.net/10541/324237
    DOI
    10.3109/01443615.2014.899330
    PubMed ID
    24725017
    Type
    Article
    Language
    en
    ISSN
    1364-6893
    ae974a485f413a2113503eed53cd6c53
    10.3109/01443615.2014.899330
    Scopus Count
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