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Noninvasive tumor hypoxia measurement using magnetic resonance imaging in murine U87 glioma xenografts and in patients with glioblastoma.

dc.contributor.authorLinnik, I V
dc.contributor.authorScott, M L J
dc.contributor.authorHolliday, K F
dc.contributor.authorWoodhouse, N l
dc.contributor.authorWaterton, J C
dc.contributor.authorO'Connor, James P B
dc.contributor.authorBarjat, H
dc.contributor.authorLiess, C
dc.contributor.authorUlloa, J
dc.contributor.authorYoung, H
dc.contributor.authorDive, Caroline
dc.contributor.authorHodgkinson, Cassandra L
dc.contributor.authorWard, Timothy H
dc.contributor.authorRoberts, Darren L
dc.contributor.authorMills, S J
dc.contributor.authorThompson, G
dc.contributor.authorBuonaccorsi, G A
dc.contributor.authorCheung, S
dc.contributor.authorJackson, A
dc.contributor.authorNaish, J H
dc.contributor.authorParker, G J M
dc.date.accessioned2014-07-08T14:49:21Z
dc.date.available2014-07-08T14:49:21Z
dc.date.issued2014-05
dc.identifier.citationNoninvasive tumor hypoxia measurement using magnetic resonance imaging in murine U87 glioma xenografts and in patients with glioblastoma. 2014, 71 (5):1854-62 Magn Reson Meden
dc.identifier.issn1522-2594
dc.identifier.pmid23798369
dc.identifier.doi10.1002/mrm.24826
dc.identifier.urihttp://hdl.handle.net/10541/322628
dc.description.abstractThere is a clinical need for noninvasive, nonionizing imaging biomarkers of tumor hypoxia and oxygenation. We evaluated the relationship of T1 -weighted oxygen-enhanced magnetic resonance imaging (OE-MRI) measurements to histopathology measurements of tumor hypoxia in a murine glioma xenograft and demonstrated technique translation in human glioblastoma multiforme.
dc.language.isoenen
dc.rightsArchived with thanks to Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicineen
dc.titleNoninvasive tumor hypoxia measurement using magnetic resonance imaging in murine U87 glioma xenografts and in patients with glioblastoma.en
dc.typeArticleen
dc.contributor.departmentCentre for Imaging Sciences, The University of Manchester, Manchester, UKen
dc.identifier.journalMagnetic Resonance in Medicineen
html.description.abstractThere is a clinical need for noninvasive, nonionizing imaging biomarkers of tumor hypoxia and oxygenation. We evaluated the relationship of T1 -weighted oxygen-enhanced magnetic resonance imaging (OE-MRI) measurements to histopathology measurements of tumor hypoxia in a murine glioma xenograft and demonstrated technique translation in human glioblastoma multiforme.


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