Noninvasive tumor hypoxia measurement using magnetic resonance imaging in murine U87 glioma xenografts and in patients with glioblastoma.

Linnik, I V; Scott, M L J; Holliday, K F; Woodhouse, N l; Waterton, J C; O'Connor, James P B; Barjat, H; Liess, C; Ulloa, J; Young, H; Dive, Caroline; Hodgkinson, Cassandra L; Ward, Timothy H; Roberts, Darren L; Mills, S J; Thompson, G; Buonaccorsi, G A; Cheung, S; Jackson, A; Naish, J H; Parker, G J M

Affiliation

Centre for Imaging Sciences, The University of Manchester, Manchester, UK

Issue Date

2014-05

Metadata

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Abstract

There is a clinical need for noninvasive, nonionizing imaging biomarkers of tumor hypoxia and oxygenation. We evaluated the relationship of T1 -weighted oxygen-enhanced magnetic resonance imaging (OE-MRI) measurements to histopathology measurements of tumor hypoxia in a murine glioma xenograft and demonstrated technique translation in human glioblastoma multiforme.

Citation

Noninvasive tumor hypoxia measurement using magnetic resonance imaging in murine U87 glioma xenografts and in patients with glioblastoma. 2014, 71 (5):1854-62 Magn Reson Med

Journal

Magnetic Resonance in Medicine

URI

http://hdl.handle.net/10541/322628

DOI

10.1002/mrm.24826

PubMed ID

23798369

Type

Article

Language

ISSN

1522-2594

Collections

All Paterson Institute for Cancer Research