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    Noninvasive tumor hypoxia measurement using magnetic resonance imaging in murine U87 glioma xenografts and in patients with glioblastoma.

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    Authors
    Linnik, I V
    Scott, M L J
    Holliday, K F
    Woodhouse, N l
    Waterton, J C
    O'Connor, James P B
    Barjat, H
    Liess, C
    Ulloa, J
    Young, H
    Dive, Caroline
    Hodgkinson, Cassandra L
    Ward, Timothy H
    Roberts, Darren L
    Mills, S J
    Thompson, G
    Buonaccorsi, G A
    Cheung, S
    Jackson, A
    Naish, J H
    Parker, G J M
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    Affiliation
    Centre for Imaging Sciences, The University of Manchester, Manchester, UK
    Issue Date
    2014-05
    
    Metadata
    Show full item record
    Abstract
    There is a clinical need for noninvasive, nonionizing imaging biomarkers of tumor hypoxia and oxygenation. We evaluated the relationship of T1 -weighted oxygen-enhanced magnetic resonance imaging (OE-MRI) measurements to histopathology measurements of tumor hypoxia in a murine glioma xenograft and demonstrated technique translation in human glioblastoma multiforme.
    Citation
    Noninvasive tumor hypoxia measurement using magnetic resonance imaging in murine U87 glioma xenografts and in patients with glioblastoma. 2014, 71 (5):1854-62 Magn Reson Med
    Journal
    Magnetic Resonance in Medicine
    URI
    http://hdl.handle.net/10541/322628
    DOI
    10.1002/mrm.24826
    PubMed ID
    23798369
    Type
    Article
    Language
    en
    ISSN
    1522-2594
    ae974a485f413a2113503eed53cd6c53
    10.1002/mrm.24826
    Scopus Count
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    All Paterson Institute for Cancer Research

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