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    Management of colorectal cancer presenting with synchronous liver metastases.

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    Authors
    Siriwardena, A
    Mason, J
    Mullamitha, Saifee A
    Hancock, H
    Jegatheeswaran, S
    Affiliation
    Hepatobiliary Surgery Unit, Manchester Biomedical Research Centre and NIHR Greater Manchester Research Network, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK.
    Issue Date
    2014-06-03
    
    Metadata
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    Abstract
    Up to a fifth of patients with colorectal cancer (CRC) present with synchronous hepatic metastases. In patients with CRC who present without intestinal obstruction or perforation and in whom comprehensive whole-body imaging confirms the absence of extrahepatic disease, evidence indicates a state of equipoise between several different management pathways, none of which has demonstrated superiority. Neoadjuvant systemic chemotherapy is advocated by current guidelines, but must be integrated with surgical management in order to remove the primary tumour and liver metastatic burden. Surgery for CRC with synchronous liver metastases can take a number of forms: the 'classic' approach, involving initial colorectal resection, interval chemotherapy and liver resection as the final step; simultaneous removal of the liver and bowel tumours with neoadjuvant or adjuvant chemotherapy; or a 'liver-first' approach (before or after systemic chemotherapy) with removal of the colorectal tumour as the final procedure. In patients with rectal primary tumours, the liver-first approach can potentially avoid rectal surgery in patients with a complete response to chemoradiotherapy. We overview the importance of precise nomenclature, the influence of clinical presentation on treatment options, and the need for accurate, up-to-date surgical terminology, staging tests and contemporary management options in CRC and synchronous hepatic metastatic disease, with an emphasis on multidisciplinary care.
    Citation
    Management of colorectal cancer presenting with synchronous liver metastases. 2014: Nat Rev Clin Oncol
    Journal
    Nature Reviews Clinical Oncology
    URI
    http://hdl.handle.net/10541/322588
    DOI
    10.1038/nrclinonc.2014.90
    PubMed ID
    24889770
    Type
    Article
    Language
    en
    ISSN
    1759-4782
    ae974a485f413a2113503eed53cd6c53
    10.1038/nrclinonc.2014.90
    Scopus Count
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