• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    High-dose interleukin 2-induced myocarditis: can myocardial damage reversibility be assessed by cardiac MRI?

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Chow, Shien
    Cove-Smith, Laura
    Schmitt, M
    Hawkins, Robert E
    Affiliation
    The Christie NHS Foundation Trust, The University of Manchester, University Hospital of South Manchester, Manchester, UK.
    Issue Date
    2014-06
    
    Metadata
    Show full item record
    Abstract
    High-dose interleukin 2 (HD-IL2) is one of the therapeutic options for patients with metastatic renal cell carcinoma. In well-selected patients with favorable clinical and pathologic features, it offers impressive response and potential long-term remission. It also has a place for treatment for metastatic malignant melanoma and in adoptive cell therapy. However, it is known for its intensive course and toxicities. Myocarditis is one of the known complications of this treatment and can pose a diagnostic challenge to treating oncologists because of its nonspecific and similar presentation to acute coronary syndrome (ACS). We report 3 short cases of HD-IL2-related myocarditis, which were either missed or misdiagnosed as ACS using conventional assessment but subsequently accurately diagnosed by cardiac magnetic resonant imaging (CMR). We discussed the clinical presentation of these cases and demonstrated the diagnostic advantage of CMR compared with standard investigations including its superior capability to assess myocardial reversibility, which has important short-term and long-term implications. The use of CMR also avoided unnecessary invasive intervention such as coronary angiogram in all 3 patients. These example cases call for effort to conduct prospective research to assess and confirm the utility of CMR, thus informing a more effective management pathway for immune-related myocarditis in HD-IL2 and other cancer immunotherapy.
    Citation
    High-dose interleukin 2-induced myocarditis: can myocardial damage reversibility be assessed by cardiac MRI? 2014, 37 (5):304-8 J Immunother
    Journal
    Journal of Immunotherapy
    URI
    http://hdl.handle.net/10541/321830
    DOI
    10.1097/CJI.0000000000000036
    PubMed ID
    24810642
    Type
    Article
    Language
    en
    ISSN
    1537-4513
    ae974a485f413a2113503eed53cd6c53
    10.1097/CJI.0000000000000036
    Scopus Count
    Collections
    All Christie Publications

    entitlement

    Related articles

    • Acute myocarditis presenting as acute coronary syndrome: role of early cardiac magnetic resonance in its diagnosis.
    • Authors: Monney PA, Sekhri N, Burchell T, Knight C, Davies C, Deaner A, Sheaf M, Baithun S, Petersen S, Wragg A, Jain A, Westwood M, Mills P, Mathur A, Mohiddin SA
    • Issue date: 2011 Aug
    • Diagnostic contribution of cardiac magnetic resonance in patients with acute coronary syndrome and culprit-free angiograms.
    • Authors: Kawecki D, Morawiec B, Monney P, Pellaton C, Wojciechowska C, Jojko J, Basiak M, Przywara-Chowaniec B, Fournier S, Nowalany-Kozielska E, Schwitter J, Muller O
    • Issue date: 2015 Jan 14
    • Evolution of acute coronary syndrome with normal coronary arteries and normal cardiac magnetic resonance imaging.
    • Authors: Chopard R, Jehl J, Dutheil J, Genon VD, Seronde MF, Kastler B, Schiele F, Meneveau N
    • Issue date: 2011 Oct
    • The diagnostic role of cardiac magnetic resonance imaging in detecting myocardial inflammation in systemic lupus erythematosus. Differentiation from viral myocarditis.
    • Authors: Mavrogeni S, Bratis K, Markussis V, Spargias C, Papadopoulou E, Papamentzelopoulos S, Constadoulakis P, Matsoukas E, Kyrou L, Kolovou G
    • Issue date: 2013 Jan
    • Diagnosis and management of patients with acute cardiac symptoms, troponin elevation and culprit-free angiograms.
    • Authors: Gallagher S, Jones DA, Anand V, Mohiddin S
    • Issue date: 2012 Jul
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.