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A new in situ hybridization and immunohistochemistry with a novel antibody to detect small T-antigen expressions of Merkel cell polyomavirus (MCPyV).

dc.contributor.authorMatsushita, M
dc.contributor.authorNonaka, Daisuke
dc.contributor.authorIwasaki, T
dc.contributor.authorKuwamoto, S
dc.contributor.authorMurakami, I
dc.contributor.authorKato, M
dc.contributor.authorNagata, K
dc.contributor.authorKitamura, Y
dc.contributor.authorHayashi, K
dc.date.accessioned2014-06-18T14:00:02Z
dc.date.available2014-06-18T14:00:02Z
dc.date.issued2014
dc.identifier.citationA new in situ hybridization and immunohistochemistry with a novel antibody to detect small T-antigen expressions of Merkel cell polyomavirus (MCPyV). 2014, 9:65 Diagn Patholen
dc.identifier.issn1746-1596
dc.identifier.pmid24649978
dc.identifier.doi10.1186/1746-1596-9-65
dc.identifier.urihttp://hdl.handle.net/10541/321819
dc.description.abstractApproximately 80% of Merkel cell carcinomas (MCCs) harbor Merkel cell polyomavirus (MCPyV) which monoclonally integrates into the genome and has prognostic significance. The presence or absence of MCPyV is usually diagnosed using CM2B4 immunohistochemistry (IHC) for MCPyV-large T antigen (LT) protein. However, this method poses a risk of misdiagnosis.
dc.language.isoenen
dc.rightsArchived with thanks to Diagnostic pathologyen
dc.titleA new in situ hybridization and immunohistochemistry with a novel antibody to detect small T-antigen expressions of Merkel cell polyomavirus (MCPyV).en
dc.typeArticleen
dc.contributor.departmentDivision of Molecular Pathology, Department of Pathology, Tottori University Faculty of Medicine, Yonago, Japan.en
dc.identifier.journalDiagnostic Pathologyen
html.description.abstractApproximately 80% of Merkel cell carcinomas (MCCs) harbor Merkel cell polyomavirus (MCPyV) which monoclonally integrates into the genome and has prognostic significance. The presence or absence of MCPyV is usually diagnosed using CM2B4 immunohistochemistry (IHC) for MCPyV-large T antigen (LT) protein. However, this method poses a risk of misdiagnosis.


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