A new in situ hybridization and immunohistochemistry with a novel antibody to detect small T-antigen expressions of Merkel cell polyomavirus (MCPyV).
Authors
Matsushita, MNonaka, Daisuke
Iwasaki, T
Kuwamoto, S
Murakami, I
Kato, M
Nagata, K
Kitamura, Y
Hayashi, K
Affiliation
Division of Molecular Pathology, Department of Pathology, Tottori University Faculty of Medicine, Yonago, Japan.Issue Date
2014
Metadata
Show full item recordAbstract
Approximately 80% of Merkel cell carcinomas (MCCs) harbor Merkel cell polyomavirus (MCPyV) which monoclonally integrates into the genome and has prognostic significance. The presence or absence of MCPyV is usually diagnosed using CM2B4 immunohistochemistry (IHC) for MCPyV-large T antigen (LT) protein. However, this method poses a risk of misdiagnosis.Citation
A new in situ hybridization and immunohistochemistry with a novel antibody to detect small T-antigen expressions of Merkel cell polyomavirus (MCPyV). 2014, 9:65 Diagn PatholJournal
Diagnostic PathologyDOI
10.1186/1746-1596-9-65PubMed ID
24649978Type
ArticleLanguage
enISSN
1746-1596ae974a485f413a2113503eed53cd6c53
10.1186/1746-1596-9-65
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