Modern radiation therapy for nodal non-Hodgkin lymphoma-target definition and dose guidelines from the International Lymphoma Radiation Oncology Group.
Authors
Illidge, Timothy MSpecht, L
Yahalom, J
Aleman, B
Berthelsen, A
Constine, L
Dabaja, B
Dharmarajan, K
Ng, A
Ricardi, U
Wirth, A
Affiliation
Institute of Cancer Sciences, University of Manchester, Manchester Academic Health Sciences Centre, The Christie National Health Service Foundation Trust, Manchester, United Kingdom.Issue Date
2014-05-01
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Show full item recordAbstract
Radiation therapy (RT) is the most effective single modality for local control of non-Hodgkin lymphoma (NHL) and is an important component of therapy for many patients. Many of the historic concepts of dose and volume have recently been challenged by the advent of modern imaging and RT planning tools. The International Lymphoma Radiation Oncology Group (ILROG) has developed these guidelines after multinational meetings and analysis of available evidence. The guidelines represent an agreed consensus view of the ILROG steering committee on the use of RT in NHL in the modern era. The roles of reduced volume and reduced doses are addressed, integrating modern imaging with 3-dimensional planning and advanced techniques of RT delivery. In the modern era, in which combined-modality treatment with systemic therapy is appropriate, the previously applied extended-field and involved-field RT techniques that targeted nodal regions have now been replaced by limiting the RT to smaller volumes based solely on detectable nodal involvement at presentation. A new concept, involved-site RT, defines the clinical target volume. For indolent NHL, often treated with RT alone, larger fields should be considered. Newer treatment techniques, including intensity modulated RT, breath holding, image guided RT, and 4-dimensional imaging, should be implemented, and their use is expected to decrease significantly the risk for normal tissue damage while still achieving the primary goal of local tumor control.Citation
Modern radiation therapy for nodal non-Hodgkin lymphoma-target definition and dose guidelines from the International Lymphoma Radiation Oncology Group. 2014, 89 (1):49-58 Int. J Radiat Oncol Biol PhysJournal
International Journal of Radiation Oncology, Biology, PhysicsDOI
10.1016/j.ijrobp.2014.01.006PubMed ID
24725689Type
ArticleLanguage
enISSN
1879-355Xae974a485f413a2113503eed53cd6c53
10.1016/j.ijrobp.2014.01.006
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