• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    No adverse affect in clinical outcome using low pre-ablation diagnostic (131)I activity in differentiated thyroid cancer: refuting thyroid stunning effect.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Yap, Beng K
    Murby, Brian
    Affiliation
    Department of Clinical Oncology, The Christie NHS Foundation Trust, Wilmslow Rd, Manchester, M20 4BX, England, U K;
    Issue Date
    2014-04-24
    
    Metadata
    Show full item record
    Abstract
    Context Published studies of thyroid stunning due to pre-ablation (131)I scanning in the treatment of differentiated thyroid cancer (DTC) following thyroidectomy had shown inconsistent clinical impact. Objective To evaluate the clinical outcome in patients who were given a low diagnostic (131)I activity (1.1mCi or 40MBq) 6 days prior to radioiodine ablation (RAI). Design/setting Two cohorts of patients treated in a cancer referral center in 2004-2011. The eligibility criteria were 1) diagnosis of differentiated thyroid carcinoma (DTC); 2) total or near total thyroidectomy; 3) no distant metastasis; 4) received ≥82.4mCi (3050MBq) therapeutic (131)I activity. Patients/Interventions 305 consecutive patients treated in 2004-2008 (group A) had a diagnostic activity 1.1mCi of (131)I prior to RAI. The second cohort treated in 2009-2011(group B) consisted of 237 patients who did not undergo diagnostic (131)I scanning prior to RAI. Main outcome measures The tumor recurrence rate at 3 years and quantitative assessment using diagnostic radioiodine scans (DxWBS) and TSH-stimulated thyroglobulin (Tg) levels at 3-12 months post RAI. Results The 3-year recurrence free survival rate were 96.4% in both groups with 4.3% in group A and 3.4% in group B had tumor recurrence (p=0.91). The ablation success rates measured by DxWBS were 97.6% and 100% and by stimulated Tg were 85.3% and 85.8% in group A and B respectively (p=0.62). Conclusions The use of low diagnostic (131)I activity (1.1mCi) given 6 days prior to RAI was safe and convenient without adversely affecting the long term clinical outcome.
    Citation
    No adverse affect in clinical outcome using low pre-ablation diagnostic (131)I activity in differentiated thyroid cancer: refuting thyroid stunning effect. 2014:20141405 J Clin Endocrinol Metab
    Journal
    The Journal of Clinical Endocrinology and Metabolism
    URI
    http://hdl.handle.net/10541/320656
    DOI
    10.1210/jc.2014-1405
    PubMed ID
    24762114
    Type
    Article
    Language
    en
    ISSN
    1945-7197
    ae974a485f413a2113503eed53cd6c53
    10.1210/jc.2014-1405
    Scopus Count
    Collections
    All Christie Publications

    entitlement

    Related articles

    • 131I therapeutic efficacy is not influenced by stunning after diagnostic whole-body scanning.
    • Authors: Dam HQ, Kim SM, Lin HC, Intenzo CM
    • Issue date: 2004 Aug
    • Influence of scanning doses of iodine-131 on subsequent first ablative treatment outcome in patients operated on for differentiated thyroid carcinoma.
    • Authors: Muratet JP, Daver A, Minier JF, Larra F
    • Issue date: 1998 Sep
    • Thyroid lobe ablation with radioactive iodine as an alternative to completion thyroidectomy after hemithyroidectomy in patients with follicular thyroid carcinoma: long-term follow-up.
    • Authors: Barbesino G, Goldfarb M, Parangi S, Yang J, Ross DS, Daniels GH
    • Issue date: 2012 Apr
    • The clinical effects of thyroid stunning after diagnostic whole-body scanning with 185 MBq 131I.
    • Authors: Lees W, Mansberg R, Roberts J, Towson J, Chua E, Turtle J
    • Issue date: 2002 Nov
    • Absence of thyroid stunning after diagnostic whole-body scanning with 185 MBq 131I.
    • Authors: Cholewinski SP, Yoo KS, Klieger PS, O'Mara RE
    • Issue date: 2000 Jul
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.