Classification of thymic epithelial neoplasms is still a challenge to thoracic pathologists: a reproducibility study using digital microscopy.
AffiliationDepartments of Pathology, Epidemiology, Biostatistics and Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York
MetadataShow full item record
AbstractContext.-Thymic epithelial tumors are rare, constituting interpretive challenges for pathologists. Digital imaging can be useful as an educational tool for these rare tumors. Objectives.-To evaluate the diagnostic reproducibility of thymic tumors among thoracic pathologists. Design.-Twenty cases of thymoma or thymic carcinoma were scanned into the Aperio system. The images were sent to pathologists with expertise in thoracic pathology at 6 different centers, who were asked to classify the tumors according to the 2004 World Heath Organization classification and to diagnose invasion. Interobserver agreement was evaluated. After discussion of the first 20 cases, a second set of 10 cases was evaluated. Results.-There was agreement for the diagnosis of thymoma and thymic carcinoma in 70% of cases (n = 14); in the remaining 6 cases, there was disagreement for cases of B3 thymoma (n = 5) and type A thymoma (n = 1) and thymic carcinoma. The overall κ was 0.39. When invasion was evaluated, the overall κ was 0.45. In the second round of the study, after discussion of diagnostic criteria, the interobserver agreement for the diagnosis of thymoma versus thymic carcinoma was 0.67 and that for the determination of invasion was 0.57-suggesting interpretative improvement. Conclusion.-The reproducibility of diagnosis of thymic epithelial tumors, using digital imaging, is comparable to that in previous studies using glass slides. Digital imaging is a good tool for remote consultation and for educational purposes. This technology could be used to train pathologists with low-level experience in thymic epithelial tumors and to foster collaborative work in the field.
CitationClassification of thymic epithelial neoplasms is still a challenge to thoracic pathologists: a reproducibility study using digital microscopy. 2014, 138 (5):658-63 Arch Pathol Lab Med
JournalArchives of Pathology & Laboratory Medicine
- Interobserver variation in the classification of thymic tumours--a multicentre study using the WHO classification system.
- Authors: Verghese ET, den Bakker MA, Campbell A, Hussein A, Nicholson AG, Rice A, Corrin B, Rassl D, Langman G, Monaghan H, Gosney J, Seet J, Kerr K, Suvarna SK, Burke M, Bishop P, Pomplun S, Willemsen S, Addis B
- Issue date: 2008 Aug
- Diagnostic significance of cell kinetic parameters in World Health Organization type A and B3 thymomas and thymic carcinomas.
- Authors: Roden AC, Yi ES, Jenkins SM, Donovan JL, Cassivi SD, Garces YI, Marks RS, Aubry MC
- Issue date: 2015 Jan
- Diagnostic reproducibility of thymic epithelial tumors using the World Health Organization classification: note for thoracic clinicians.
- Authors: Sakakura N, Tateyama H, Nakamura S, Taniguchi T, Usami N, Ishikawa Y, Kawaguchi K, Yokoi K
- Issue date: 2013 Feb
- Interobserver variation in the classification of thymic lesions including biopsies and resection specimens in an international digital microscopy panel.
- Authors: Wolf JL, van Nederveen F, Blaauwgeers H, Marx A, Nicholson AG, Roden AC, Ströbel P, Timens W, Weissferdt A, von der Thüsen J, den Bakker MA
- Issue date: 2020 Nov
- Reproducibility of 3 histologic classifications and 3 staging systems for thymic epithelial neoplasms and its effect on prognosis.
- Authors: Roden AC, Yi ES, Jenkins SM, Edwards KK, Donovan JL, Lewis JE, Cassivi SD, Marks RS, Garces YI, Aubry MC
- Issue date: 2015 Apr