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    Everolimus for women with trastuzumab-resistant, HER2-positive, advanced breast cancer (BOLERO-3): a randomised, double-blind, placebo-controlled phase 3 trial.

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    Authors
    André, F
    O'Regan, R
    Ozguroglu, M
    Toi, M
    Xu, B
    Jerusalem, G
    Masuda, N
    Wilks, S
    Arena, F
    Isaacs, C
    Yap, Y
    Papai, Z
    Lang, I
    Armstrong, Anne C
    Lerzo, G
    White, M
    Shen, K
    Litton, J
    Chen, D
    Zhang, Y
    Ali, S
    Taran, T
    Gianni, L
    Show allShow less
    Affiliation
    Department of Medical Oncology, INSERM Unit U981, Université Paris Sud, Institut Gustave Roussy, Villejuif, France.
    Issue Date
    2014-05
    
    Metadata
    Show full item record
    Abstract
    Disease progression in patients with HER2-positive breast cancer receiving trastuzumab might be associated with activation of the PI3K/Akt/mTOR intracellular signalling pathway. We aimed to assess whether the addition of the mTOR inhibitor everolimus to trastuzumab might restore sensitivity to trastuzumab.
    Citation
    Everolimus for women with trastuzumab-resistant, HER2-positive, advanced breast cancer (BOLERO-3): a randomised, double-blind, placebo-controlled phase 3 trial. 2014, 15 (6):580-91 Lancet Oncol
    Journal
    The Lancet Oncology
    URI
    http://hdl.handle.net/10541/320611
    DOI
    10.1016/S1470-2045(14)70138-X
    PubMed ID
    24742739
    Type
    Article
    Language
    en
    ISSN
    1474-5488
    ae974a485f413a2113503eed53cd6c53
    10.1016/S1470-2045(14)70138-X
    Scopus Count
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