Optimisation of an immunohistochemistry method for the determination of androgen receptor expression levels in circulating tumour cells.
Authors
Cummings, JeffreySloane, Robert
Morris, Karen
Zhou, Cong
Lancashire, Matthew
Moore, David
Elliott, Tony
Clarke, Noel W
Dive, Caroline
Affiliation
Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester Cancer Research Centre, Manchester M20 4BX, UK. jcummings@picr.man.ac.ukIssue Date
2014
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Show full item recordAbstract
AZD3514 inhibits and down regulates the androgen receptor (AR) and has undergone clinical trials in prostate cancer. To provide proof-of-mechanism (POM) in patients, an immunohistochemistry (IHC) method for determination of AR in circulating tumour cells (CTC) was developed and validated.Citation
Optimisation of an immunohistochemistry method for the determination of androgen receptor expression levels in circulating tumour cells. 2014, 14 (1):226 BMC CancerJournal
BMC CancerDOI
10.1186/1471-2407-14-226PubMed ID
24674711Type
ArticleLanguage
enISSN
1471-2407ae974a485f413a2113503eed53cd6c53
10.1186/1471-2407-14-226
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